Nephro-Urology Monthly

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Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit

Mahmoud Gholyaf 1 , * , Zahra Basiri 2 , Tahmasb Taghizadeh 3 , Eghlim Nemati 4 , Mehrdad Taghipour 4 and Mohsen Motalebi 4
Authors Information
1 Department of Nephrology, Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2 Rheumatology Department, Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
3 Internal Medicinel Department, Sina Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
4 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Article information
  • Nephro-Urology Monthly: July 2017, 9 (4); e14007
  • Published Online: June 7, 2017
  • Article Type: Research Article
  • Received: August 18, 2014
  • Revised: October 15, 2014
  • Accepted: April 29, 2017
  • DOI: 10.5812/numonthly.14007

To Cite: Gholyaf M, Basiri Z, Taghizadeh T, Nemati E, Taghipour M, et al. Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit, Nephro-Urol Mon. 2017 ; 9(4):e14007. doi: 10.5812/numonthly.14007.

Copyright © 2017, Nephro-Urology Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Tong GM, Rude RK. Magnesium deficiency in critical illness. J Intensive Care Med. 2005; 20(1): 3-17[DOI][PubMed]
  • 2. Escuela MP, Guerra M, Anon JM, Martinez-Vizcaino V, Zapatero MD, Garcia-Jalon A, et al. Total and ionized serum magnesium in critically ill patients. Intensive Care Med. 2005; 31(1): 151-6[DOI][PubMed]
  • 3. Bohl CH, Volpe SL. Magnesium and exercise. Crit Rev Food Sci Nutr. 2002; 42(6): 533-63[DOI][PubMed]
  • 4. Cinar V, Mogulkoc R, Baltaci AK, Nizamlioglu M. Effect of magnesium supplementation on some plasma elements in athletes at rest and exhaustion. Biol Trace Elem Res. 2007; 119(2): 97-102[DOI][PubMed]
  • 5. Cinar V, Mogulkoc R, Baltaci AK, Polat Y. Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: effects of magnesium supplementation. Biol Trace Elem Res. 2008; 121(3): 215-20[DOI][PubMed]
  • 6. Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000; 72(2 Suppl): 585S-93S[PubMed]
  • 7. Van Loan MD, Sutherland B, Lowe NM, Turnlund JR, King JC. The effects of zinc depletion on peak force and total work of knee and shoulder extensor and flexor muscles. Int J Sport Nutr. 1999; 9(2): 125-35[PubMed]
  • 8. Williams M. Dietary supplements and sports performance: amino acids. Int J Sport Nutr. 2005; 2: 63-7
  • 9. Carvil P, Cronin J. Magnesium and Implications on Muscle Function. Strength Cond J . 2010; 32(1): 48-54
  • 10. Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnesium research : Official organ of the international society for the development of research on magnesium. 2006; 19: 180-9
  • 11. Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, et al. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr. 2006; 84(2): 419-26[PubMed]
  • 12. al-Ghamdi SM, Cameron EC, Sutton RA. Magnesium deficiency: pathophysiologic and clinical overview. Am J Kidney Dis. 1994; 24(5): 737-52[PubMed]
  • 13. Touyz RM. Magnesium in clinical medicine. Front Biosci. 2004; 9: 1278-93[PubMed]
  • 14. Rubeiz GJ, Thill-Baharozian M, Hardie D, Carlson RW. Association of hypomagnesemia and mortality in acutely ill medical patients. Crit Care Med. 1993; 21(2): 203-9[PubMed]
  • 15. Mazdeh M, Torabian S. Comparison of serum levels of magnesium and potassium in stroke patient and healthy controls. J Fasa Univ Med Sci. 2011; 1(2): 7-13
  • 16. Huijgen HJ, Soesan M, Sanders R, Mairuhu WM, Kesecioglu J, Sanders GT. Magnesium levels in critically ill patients. What should we measure? Am J Clin Pathol. 2000; 114(5): 688-95[DOI][PubMed]
  • 17. Sabatier M, Pont F, Arnaud MJ, Turnlund JR. A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. Am J Physiol Regul Integr Comp Physiol. 2003; 285(3)-63[DOI][PubMed]
  • 18. Ryzen E, Wagers PW, Singer FR, Rude RK. Magnesium deficiency in a medical ICU population. Crit Care Med. 1985; 13(1): 19-21[PubMed]
  • 19. Rude RK. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 1993; 22(2): 377-95[PubMed]
  • 20. Grubbs RD, Maguire ME. Magnesium as a regulatory cation: criteria and evaluation. Magnesium. 1987; 6(3): 113-27[PubMed]
  • 21. McNair P, Christensen MS, Christiansen C, Madsbad S, Transbol I. Renal hypomagnesaemia in human diabetes mellitus: its relation to glucose homeostasis. Eur J Clin Invest. 1982; 12(1): 81-5[PubMed]
  • 22. Pham PC, Pham PM, Pham PA, Pham SV, Pham HV, Miller JM, et al. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clin Nephrol. 2005; 63(6): 429-36[PubMed]
  • 23. Spiegel DM. Magnesium in chronic kidney disease: unanswered questions. Blood Purif. 2011; 31(1-3): 172-6[DOI][PubMed]
  • 24. Chernow B, Bamberger S, Stoiko M, Vadnais M, Mills S, Hoellerich V, et al. Hypomagnesemia in patients in postoperative intensive care. Chest. 1989; 95(2): 391-7[PubMed]
  • 25. Fiaccadori E, Del Canale S, Coffrini E, Melej R, Vitali P, Guariglia A, et al. Muscle and serum magnesium in pulmonary intensive care unit patients. Crit Care Med. 1988; 16(8): 751-60[PubMed]
  • 26. Deheinzelin D, Negri EM, Tucci MR, Salem MZ, da Cruz VM, Oliveira RM, et al. Hypomagnesemia in critically ill cancer patients: a prospective study of predictive factors. Braz J Med Biol Res. 2000; 33(12): 1443-8[PubMed]
  • 27. Kahraman S, Ozgurtas T, Kayali H, Atabey C, Kutluay T, Timurkaynak E. Monitoring of serum ionized magnesium in neurosurgical intensive care unit: preliminary results. Clinica Chimica Acta; Inter J Clin Chem. 2003; 334(1-2): 211-5
  • 28. Soliman HM, Mercan D, Lobo SS, Melot C, Vincent JL. Development of ionized hypomagnesemia is associated with higher mortality rates. Crit Care Med. 2003; 31(4): 1082-7[DOI][PubMed]
  • 29. Alexander RT, Hoenderop JG, Bindels RJ. Molecular determinants of magnesium homeostasis: insights from human disease. J Am Soc Nephrol. 2008; 19(8): 1451-8[DOI][PubMed]
  • 30. Dabbagh OC, Aldawood AS, Arabi YM, Lone NA, Brits R, Pillay M. Magnesium supplementation and the potential association with mortality rates among critically ill non-cardiac patients. Saudi Med J. 2006; 27(6): 821-5[PubMed]
  • 31. Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med. 1996; 156(11): 1143-8[PubMed]
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