When Should Commence Dialysis: Focusing on the Predialysis Condition

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To Cite : Maffei S, Savoldi S, Triolo G. When Should Commence Dialysis: Focusing on the Predialysis Condition, Nephro-Urol Mon. 2013 ;5(2):723-7. doi: 10.5812/numonthly.5435.
1. Background
2. The Role of the “Early Referral”
3. The Problem of the
4. Timing of Dialysis Initiation
5. Conclusion
  • 1. Levin A. The advantage of a uniform terminology and staging system for chronic kidney disease (CKD). Nephrol Dial Transplant. 2003; 18(8): 1446-51[PubMed]
  • 2. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2 Suppl 1)-266[PubMed]
  • 3. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004; 351(13): 1296-305[DOI][PubMed]
  • 4. Kinney R. 2005 Annual Report: ESRD Clinical Performance Measures Project. Am J Kidney Dis. 2006; 48(4 Suppl 2)-106[DOI][PubMed]
  • 5. Klang B, Bjorvell H, Berglund J, Sundstedt C, Clyne N. Predialysis patient education: effects on functioning and well-being in uraemic patients. J Adv Nurs. 1998; 28(1): 36-44[PubMed]
  • 6. Stevens LA, Fares G, Fleming J, Martin D, Murthy K, Qiu J, et al. Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol. 2005; 16(8): 2439-48[DOI][PubMed]
  • 7. Schwenger V, Morath C, Hofmann A, Hoffmann O, Zeier M, Ritz E. Late referral--a major cause of poor outcome in the very elderly dialysis patient. Nephrol Dial Transplant. 2006; 21(4): 962-7[DOI][PubMed]
  • 8. Winkelmayer WC, Owen WF, Jr, Levin R, Avorn J. A propensity analysis of late versus early nephrologist referral and mortality on dialysis. J Am Soc Nephrol. 2003; 14(2): 486-92[PubMed]
  • 9. Buck J, Baker R, Cannaby AM, Nicholson S, Peters J, Warwick G. Why do patients known to renal services still undergo urgent dialysis initiation? A cross-sectional survey. Nephrol Dial Transplant. 2007; 22(11): 3240-5[DOI][PubMed]
  • 10. Curtis BM, Ravani P, Malberti F, Kennett F, Taylor PA, Djurdjev O, et al. The short- and long-term impact of multi-disciplinary clinics in addition to standard nephrology care on patient outcomes. Nephrol Dial Transplant. 2005; 20(1): 147-54[DOI][PubMed]
  • 11. Goldstein M, Yassa T, Dacouris N, McFarlane P. Multidisciplinary predialysis care and morbidity and mortality of patients on dialysis. Am J Kidney Dis. 2004; 44(4): 706-14[PubMed]
  • 12. Mehrotra R, Marsh D, Vonesh E, Peters V, Nissenson A. Patient education and access of ESRD patients to renal replacement therapies beyond in-center hemodialysis. Kidney Int. 2005; 68(1): 378-90[DOI][PubMed]
  • 13. Ravani P, Brunori G, Mandolfo S, Cancarini G, Imbasciati E, Marcelli D, et al. Cardiovascular comorbidity and late referral impact arteriovenous fistula survival: a prospective multicenter study. J Am Soc Nephrol. 2004; 15(1): 204-9[PubMed]
  • 14. US Renal Data System: USRDS 2004 Annual Data Report. The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases .
  • 15. Obrador GT, Arora P, Kausz AT, Ruthazer R, Pereira BJ, Levey AS. Level of renal function at the initiation of dialysis in the U.S. end-stage renal disease population. Kidney Int. 1999; 56(6): 2227-35[DOI][PubMed]
  • 16. Bonomini V, Feletti C, Stefoni S, Vangelista A. Early dialysis and renal transplantation. Nephron. 1986; 44(4): 267-71[PubMed]
  • 17. Tattersall J, Greenwood R, Farrington K. Urea kinetics and when to commence dialysis. Am J Nephrol. 1995; 15(4): 283-9[PubMed]
  • 18. Beddhu S, Samore MH, Roberts MS, Stoddard GJ, Ramkumar N, Pappas LM, et al. Impact of timing of initiation of dialysis on mortality. J Am Soc Nephrol. 2003; 14(9): 2305-12[PubMed]
  • 19. Ifudu O, Dawood M, Homel P, Friedman EA. Timing of initiation of uremia therapy and survival in patients with progressive renal disease. Am J Nephrol. 1998; 18(3): 193-8[PubMed]
  • 20. Korevaar JC, Jansen MA, Dekker FW, Jager KJ, Boeschoten EW, Krediet RT, et al. When to initiate dialysis: effect of proposed US guidelines on survival. Lancet. 2001; 358(9287): 1046-50[DOI][PubMed]
  • 21. Lassalle M, Labeeuw M, Frimat L, Villar E, Joyeux V, Couchoud C, et al. Age and comorbidity may explain the paradoxical association of an early dialysis start with poor survival. Kidney Int. 2010; 77(8): 700-7[DOI][PubMed]
  • 22. Sesso R, Belasco AG. Late diagnosis of chronic renal failure and mortality on maintenance dialysis. Nephrol Dial Transplant. 1996; 11(12): 2417-20[PubMed]
  • 23. Stel VS, Dekker FW, Ansell D, Augustijn H, Casino FG, Collart F, et al. Residual renal function at the start of dialysis and clinical outcomes. Nephrol Dial Transplant. 2009; 24(10): 3175-82[DOI][PubMed]
  • 24. Traynor JP, Simpson K, Geddes CC, Deighan CJ, Fox JG. Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol. 2002; 13(8): 2125-32[PubMed]
  • 25. Kazmi WH, Gilbertson DT, Obrador GT, Guo H, Pereira BJ, Collins AJ, et al. Effect of comorbidity on the increased mortality associated with early initiation of dialysis. Am J Kidney Dis. 2005; 46(5): 887-96[DOI][PubMed]
  • 26. Cooper BA, Branley P, Bulfone L, Collins JF, Craig JC, Dempster J, et al. The Initiating Dialysis Early and Late (IDEAL) study: study rationale and design. Perit Dial Int. 2004; 24(2): 176-81[PubMed]
  • 27. Harris A, Cooper BA, Li JJ, Bulfone L, Branley P, Collins JF, et al. Cost-effectiveness of initiating dialysis early: a randomized controlled trial. Am J Kidney Dis. 2011; 57(5): 707-15[DOI][PubMed]
  • 28. Scalone L, Borghetti F, Brunori G, Viola BF, Brancati B, Sottini L, et al. Cost-benefit analysis of supplemented very low-protein diet versus dialysis in elderly CKD5 patients. Nephrol Dial Transplant. 2010; 25(3): 907-13[DOI][PubMed]
  • 29. Brunori G, Viola BF, Parrinello G, De Biase V, Como G, Franco V, et al. Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a prospective randomized multicenter controlled study. Am J Kidney Dis. 2007; 49(5): 569-80[DOI][PubMed]
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