Nephro-Urology Monthly

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Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female

Mehdi Nematbakhsh 1 , 2 , 3 , * , Shadi Ebrahimian 1 , Mona Tooyserkani 1 , Fatemeh Eshraghi-Jazi 1 , Ardeshir Talebi 1 , 4 and Farzaneh Ashrafi 1 , 5
Authors Information
1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran
3 Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran
4 Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran
5 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Nephro-Urology Monthly: July 01, 2013, 5 (3); 818-21
  • Published Online: June 25, 2013
  • Article Type: Research Article
  • Received: January 5, 2013
  • Revised: February 9, 2013
  • Accepted: February 23, 2013
  • DOI: 10.5812/numonthly.10128

To Cite: Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, et al. Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female, Nephro-Urol Mon. 2013 ; 5(3):818-21. doi: 10.5812/numonthly.10128.

Abstract
Copyright © 2013, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Bennett WM, Parker RA, Elliott WC, Gilbert DN, Houghton DC. Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity. J Infect Dis. 1982; 145(3): 370-3[PubMed]
  • 2. Ali BH, Ben Ismail TH, Basheer AA. Sex difference in the susceptibility of rats to gentamicin nephrotoxicity: Influence of gonadectomy and hormonal replacement therapy. Indian J Pharmacol. 2001; 33(5): 369-73
  • 3. Laniado-Laborin R, Cabrales-Vargas MN. Amphotericin B: side effects and toxicity. Rev Iberoam Micol. 2009; 26(4): 223-7[DOI][PubMed]
  • 4. Goodrich JA, Hottendorf GH. Tobramycin gender-related nephrotoxicity in Fischer but not Sprague-Dawley rats. Toxicol Lett. 1995; 75(1-3): 127-31[PubMed]
  • 5. Hong SK, Anestis DK, Valentovic MA, Ball JG, Brown PI, Rankin GO. Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital. J Toxicol Environ Health A. 2001; 64(3): 241-56[DOI][PubMed]
  • 6. Takayama J, Takaoka M, Sugino Y, Yamamoto Y, Ohkita M, Matsumura Y. Sex difference in ischemic acute renal failure in rats: approach by proteomic analysis. Biol Pharm Bull. 2007; 30(10): 1905-12[PubMed]
  • 7. Wongtawatchai T, Agthong S, Kaewsema A, Chentanez V. Sex-related differences in cisplatin-induced neuropathy in rats. J Med Assoc Thai. 2009; 92(11): 1485-91[PubMed]
  • 8. Nematbakhsh M, Pezeshki Z, Eshraghi-Jazi F, Ashrafi F, Nasri H, Talebi A, et al. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model. Int J Nephrol. 2012; 2012: 284896[DOI][PubMed]
  • 9. Eshraghi-Jazi F, Nematbakhsh M, Nasri H, Talebi A, Haghighi M, Pezeshki Z, et al. The protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model. J Res Med Sci. 2011; 16(11): 1389-96[PubMed]
  • 10. Haghighi M, Nematbakhsh M, Talebi A, Nasri H, Ashrafi F, Roshanaei K, et al. The role of angiotensin II receptor 1 (AT1) blockade in cisplatin-induced nephrotoxicity in rats: gender-related differences. Ren Fail. 2012; 34(8): 1046-51[DOI][PubMed]
  • 11. Nematbakhsh M, Talebi A, Nasri H, Safari T, Dolatkhah S, Ashrafi F, et al. Some evidence for sex-based differences in cisplatin-induced nephrotoxicity in rats. Clin Exp Med Lett. 2012; 53(1-2): 29-31
  • 12. Botsoglou Nickos A, Fletouris Dimitrios J, Papageorgiou Georgios E, Vassilopoulos Vassilios N, Mantis Antonios J, Trakatellis Antonios G. Rapid, sensitive, and specific thiobarbituric acid method for measuring lipid peroxidation in animal tissue, food, and feedstuff samples. J Agricultur Food Chem 1994; 42(9): 1931-1937
  • 13. Sweileh WM. Gender differences in aminoglycoside induced nephrotoxicity: a prospective, hospital-based study. Curr Clin Pharmacol. 2009; 4(3): 229-32[PubMed]
  • 14. Stakisaitis D, Dudeniene G, Jankunas RJ, Grazeliene G, Didziapetriene J, Pundziene B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina (Kaunas). 2010; 46(1): 45-50[PubMed]
  • 15. Carraro-Eduardo JC, Oliveira AV, Carrapatoso ME, Ornellas JF. Effect of sex hormones on gentamicin-induced nephrotoxicity in rats. Braz J Med Biol Res. 1993; 26(6): 653-62[PubMed]
  • 16. Pezeshki Z, Nematbakhsh M, Mazaheri S, Eshraghi-Jazi F, Talebi A, Nasri H, et al. Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats. ISRN Oncol. 2012; 2012: 890310[DOI][PubMed]
  • 17. Safari T, Nematbakhsh M, Hilliard LM, Evans RG, Denton KM. Sex differences in the renal vascular response to angiotensin II involves the Mas receptor. Acta Physiol (Oxf). 2012; 206(2): 150-6[DOI][PubMed]
  • 18. Hilliard LM, Nematbakhsh M, Kett MM, Teichman E, Sampson AK, Widdop RE, et al. Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor. Hypertension. 2011; 57(2): 275-82[DOI][PubMed]
  • 19. Winston JA, Safirstein R. Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat. Am J Physiol. 1985; 249(4 Pt 2)-6[PubMed]
  • 20. Miura K, Pasino DA, Goldstein RS, Hook JB. Effects of gentamicin on renal function in isolated perfused kidneys from male and female rats. Toxicol Lett. 1985; 26(1): 15-8
  • 21. Williams PD, Hottendorf GH. [3H]gentamicin uptake in brush border and basolateral membrane vesicles from rat kidney cortex. Biochem Pharmacol. 1986; 35(13): 2253-6[PubMed]
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