Nephro-Urology Monthly

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Comparative Study of Intravenous Iron Versus Intravenous Ascorbic Acid for Treatment of Functional Iron Deficiency in Patients Under Hemodialysis. A Randomized Clinical Trial

Omid Sedighi 1 , Atieh Makhlough 2 , * , Ghasem Janbabai 3 and Mohammad Neemi 4
Authors Information
1 Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
2 Molecular and Cell Biology Research Center, Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Department of Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
4 Department of Internal Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Nephro-Urology Monthly: September 01, 2013, 5 (4); 913-917
  • Published Online: July 24, 2013
  • Article Type: Research Article
  • Received: May 11, 2013
  • Revised: May 30, 2013
  • Accepted: June 8, 2013
  • DOI: 10.5812/numonthly.12038

To Cite: Sedighi O, Makhlough A, Janbabai G, Neemi M. Comparative Study of Intravenous Iron Versus Intravenous Ascorbic Acid for Treatment of Functional Iron Deficiency in Patients Under Hemodialysis. A Randomized Clinical Trial, Nephro-Urol Mon. 2013 ; 5(4):913-917. doi: 10.5812/numonthly.12038.

Abstract
Copyright © 2013, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Amgen CA. Thousand oaks 2007;
  • 2. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis. 2006; 47(5 Suppl 3)-145[DOI][PubMed]
  • 3. Coyne D. Iron indices: what do they really mean? Kidney Int Suppl. 2006; (101)-8[PubMed]
  • 4. Fishbane S, Kalantar-Zadeh K, Nissenson AR. Serum ferritin in chronic kidney disease: reconsidering the upper limit for iron treatment. Semin Dial. 2004; 17(5): 336-41[DOI][PubMed]
  • 5. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant. 2004; 19(1): 141-9[PubMed]
  • 6. Keyhanian S, Taziki O. Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hyperferritinemia. Saudi J Kidney Dis Transpl. 2008; 19(6): 933-6[PubMed]
  • 7. Attallah N, Osman-Malik Y, Frinak S, Besarab A. Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia. Am J Kidney Dis. 2006; 47(4): 644-54[DOI][PubMed]
  • 8. Gouva C, Nikolopoulos P, Ioannidis JP, Siamopoulos KC. Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial. Kidney Int. 2004; 66(2): 753-60[DOI][PubMed]
  • 9. Vlagopoulos PT, Tighiouart H, Weiner DE, Griffith J, Pettitt D, Salem DN, et al. Anemia as a risk factor for cardiovascular disease and all-cause mortality in diabetes: the impact of chronic kidney disease. J Am Soc Nephrol. 2005; 16(11): 3403-10[DOI][PubMed]
  • 10. Kinney R. 2005 Annual Report: ESRD Clinical Performance Measures Project. Am J Kidney Dis 2006; 48
  • 11. Kopelman RC, Smith L, Peoples L, Biesecker R, Rizkala AR. Functional iron deficiency in hemodialysis patients with high ferritin. Hemodial Int. 2007; 11(2): 238-46[DOI][PubMed]
  • 12. Coyne DW, Kapoian T, Suki W, Singh AK, Moran JE, Dahl NV, et al. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study. J Am Soc Nephrol. 2007; 18(3): 975-84[DOI][PubMed]
  • 13. Kapoian T, O'Mara NB, Singh AK, Moran J, Rizkala AR, Geronemus R, et al. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. J Am Soc Nephrol. 2008; 19(2): 372-9[DOI][PubMed]
  • 14. Singh AK, Coyne DW, Shapiro W, Rizkala AR. Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation. Kidney Int. 2007; 71(11): 1163-71[DOI][PubMed]
  • 15. Tarng DC, Huang TP. A parallel, comparative study of intravenous iron versus intravenous ascorbic acid for erythropoietin-hyporesponsive anaemia in haemodialysis patients with iron overload. Nephrol Dial Transplant. 1998; 13(11): 2867-72[PubMed]
  • 16. Taji Y, Morimoto T, Okada K, Fukuhara S, Fukui T, Kuwahara T. Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients. J Nephrol. 2004; 17(4): 537-43[PubMed]
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