Nephro-Urology Monthly

Published by: Kowsar

Rationale for the Use of Prostaglandins and Phosphodiesterase Inhibitors in the Treatment of Functional Bladder Disorders

Mohammad Sajjad Rahnama'i 1 , * , Gommert A. Van Koeveringe 1 and Philip E. Van Kerrebroeck 1
Authors Information
1 Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands
Article information
  • Nephro-Urology Monthly: November 01, 2013, 5 (5); 949-954
  • Published Online: November 13, 2013
  • Article Type: Review Article
  • Received: August 7, 2013
  • Accepted: September 11, 2013
  • DOI: 10.5812/numonthly.14088

To Cite: Rahnama'i M S, Van Koeveringe G A, Van Kerrebroeck P E. Rationale for the Use of Prostaglandins and Phosphodiesterase Inhibitors in the Treatment of Functional Bladder Disorders, Nephro-Urol Mon. 2013 ; 5(5):949-954. doi: 10.5812/numonthly.14088.

Copyright © 2013, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. EP1 and EP2 Distribution in the Bladder Wall
3. The EP1/EP2 Balance Hypothesis
4. Autonomous Bladder Activity
5. The PGE2 Signal and OAB
6. The Effect of COX Inhibition
7. The Role of PDE’s in the Bladder
8. Future Perspectives
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