Nephro-Urology Monthly

Published by: Kowsar

Bilateral Laparoscopic Gonadectomy in a Patient With Complete Androgen Insensitivity Syndrome and Bilateral Sertoli-Leydig Cell Tumor: A Case Report and Brief Review of the Literature

Mohammad Asl Zare 1 , Mahmood Reza Kalantari 2 , Amir Abbas Asadpour 1 and Ali Kamalati 3 , *
Authors Information
1 Department of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Urology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran
Article information
  • Nephro-Urology Monthly: May 01, 2014, 6 (3); e15278
  • Published Online: April 21, 2014
  • Article Type: Case Report
  • Received: October 6, 2013
  • Revised: December 2, 2013
  • Accepted: January 11, 2014
  • DOI: 10.5812/numonthly.15278

To Cite: Asl Zare M, Kalantari M R, Asadpour A A, Kamalati A. Bilateral Laparoscopic Gonadectomy in a Patient With Complete Androgen Insensitivity Syndrome and Bilateral Sertoli-Leydig Cell Tumor: A Case Report and Brief Review of the Literature, Nephro-Urol Mon. 2014 ; 6(3):e15278. doi: 10.5812/numonthly.15278.

Abstract
Copyright © 2014, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
Acknowledgements
Footnotes
References
  • 1. Sharma S, Balwan WK, Kumar P, Gupta S. Androgen insensitivity syndrome (testicular feminization). J Obstet Gynaecol India. 2012; 62(2): 199-201[DOI][PubMed]
  • 2. Galani A, Kitsiou-Tzeli S, Sofokleous C, Kanavakis E, Kalpini-Mavrou A. Androgen insensitivity syndrome: clinical features and molecular defects. Hormones (Athens). 2008; 7(3): 217-29[PubMed]
  • 3. Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol. 1953; 65(6): 1192-211[PubMed]
  • 4. Bowen P, Lee CS, Migeon CJ, Kaplan NM, Whalley PJ, McKusick VA, et al. Hereditary Male Pseudohermaphroditism with Hypogonadism, Hypospadias, and Gynecomastia: Reifenstein's Syndrome. Ann Intern Med. 1965; 62: 252-70[PubMed]
  • 5. Goldberg MB, Maxwell AF. Male pseudohermaphroditism proved by surgical exploration and microscopic examination; a case report with speculations concerning pathogenesis. J Clin Endocrinol Metab. 1948; 8(5): 367-79[DOI][PubMed]
  • 6. Hughes IA, Deeb A. Androgen resistance. Best Pract Res Clin Endocrinol Metab. 2006; 20(4): 577-98[DOI][PubMed]
  • 7. Grumbach MN. Williams textbook of endocrinology 2003; : 842-1002
  • 8. Bangsboll S, Qvist I, Lebech PE, Lewinsky M. Testicular feminization syndrome and associated gonadal tumors in Denmark. Acta Obstet Gynecol Scand. 1992; 71(1): 63-6[PubMed]
  • 9. Boehmer AL, Brinkmann O, Bruggenwirth H, van Assendelft C, Otten BJ, Verleun-Mooijman MC, et al. Genotype versus phenotype in families with androgen insensitivity syndrome. J Clin Endocrinol Metab. 2001; 86(9): 4151-60[DOI][PubMed]
  • 10. Baksu A, Kabukcuoglu F, Baksu B, Goker N. Bilateral sertoli cell adenoma and serous cyst in a patient with androgen insensitivity syndrome. Eur J Obstet Gynecol Reprod Biol. 2004; 114(1): 104-7[DOI][PubMed]
  • 11. Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T. Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol. 2005; 96(3): 870-2[DOI][PubMed]
  • 12. Nguyen BD. PET imaging of Sertoli cell tumor in androgen insensitivity syndrome. Clin Nucl Med. 2003; 28(9): 743-5[DOI][PubMed]
  • 13. Rutgers JL, Scully RE. The androgen insensitivity syndrome (testicular feminization): a clinicopathologic study of 43 cases. Int J Gynecol Pathol. 1991; 10(2): 126-44[PubMed]
  • 14. Wysocka B, Serkies K, Debniak J, Jassem J, Limon J. Sertoli cell tumor in androgen insensitivity syndrome--a case report. Gynecol Oncol. 1999; 75(3): 480-3[DOI][PubMed]
  • 15. Jarzabek K, Philibert P, Koda M, Sulkowski S, Kotula-Balak M, Bilinska B, et al. Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli-Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. Gynecol Endocrinol. 2007; 23(9): 499-504[DOI][PubMed]
  • 16. Ozulker T, Ozpacaci T, Ozulker F, Ozekici U, Bilgic R, Mert M. Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. Ann Nucl Med. 2010; 24(1): 35-9[DOI][PubMed]
  • 17. Connell MJ, Ramsey HE, Whang-Peng J, Wiernik PH. Testicular feminization syndrome in three sibs: emphasis on gonadal neoplasia. Am J Med Sci. 1973; 265(4): 321-33[PubMed]
  • 18. Damjanov I, Nesbitt KA, Reardon MP, Vidone RA. Giant sertoli cell adenoma in testicular feminization syndrome. Obstet Gynecol. 1976; 48(5): 624-7[PubMed]
  • 19. Ramaswamy G, Jagadha V, Tchertkoff V. A testicular tumor resembling the sex cord with annular tubules in a case of the androgen insensitivity syndrome. Cancer. 1985; 55(7): 1607-11[PubMed]
  • 20. Ko HM, Chung JH, Lee JH, Jung IS, Choi IS, Juhng SW, et al. Androgen receptor gene mutation associated with complete androgen insensitivity syndrome and Sertoli cell adenoma. Int J Gynecol Pathol. 2001; 20(2): 196-9[PubMed]
  • 21. Fleckenstein GH, Gunawan B, Brinck U, Wuttke W, Emons G. Simultaneous sertoli cell tumor and adenocarcinoma of the tunica vaginalis testis in a patient with testicular feminization. Gynecol Oncol. 2002; 84(3): 460-3[DOI][PubMed]
  • 22. Min-Sung C, So-Young J, Sang-Mo P, Dong-Wha L. A Sertoli-Leydig Cell Tumor in a Patient with Complete Androgen Insensitivity Syndrome-A Case Report. Korean J Pathol. 2007; 41: 59-62
  • 23. Scully RE, Galdabini JJ, McNeely BU. Case records of the Massachusetts General Hospital (Case 8—1977). N Engl J Med. 1977; 296(8): 439–44
  • 24. Knoke I, Jakubiczka S, Ottersen T, Goppinger A, Wieacker P. A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor. Cancer Genet Cytogenet. 1997; 98(2): 139-41[PubMed]
  • 25. Lentz SS, Cappellari JO. Postmenopausal diagnosis of testicular feminization. Am J Obstet Gynecol. 1998; 179(1): 268-9[PubMed]
  • 26. Detre Z, Bujdoso G. Testicular feminization syndrome with Sertoli cell adenoma. Pathol Res Pract. 1984; 178(4): 403-6[PubMed]
  • 27. Lin MH, Shamszadeh M, Pitukcheewanont P. Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. J Pediatr Endocrinol Metab. 2012; 25(5-6): 547-51[PubMed]
  • 28. Hannema SE, Scott IS, Rajpert-De Meyts E, Skakkebaek NE, Coleman N, Hughes IA. Testicular development in the complete androgen insensitivity syndrome. J Pathol. 2006; 208(4): 518-27[DOI][PubMed]
  • 29. Ayhan A, Tuncer ZS, Hakverdi AU, Yuce K, Ayhan A. Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases. Eur J Gynaecol Oncol. 1996; 17(1): 75-8[PubMed]
  • 30. Choong CS, Fuller PJ, Chu S, Jeske Y, Bowling F, Brown R, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002; 87(1): 49-56[PubMed]
Readers' Comments