Nephro-Urology Monthly

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Association Between Plasma Selenium and Glutathione Peroxidase Levels And Severity of Diabetic Nephropathy in Patients With Type Two Diabetes Mellitus

Omid Sedighi 1 , Atieh Makhlough 2 , * , Mohammad Shokrzadeh 3 and Shiva Hoorshad 4
Authors Information
1 Department of Nephrology, Faculty of Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
2 Diabetes Research Center, Faculty of Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Pharmaceutical Sciences Research Center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran
4 Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Nephro-Urology Monthly: September 01, 2014, 6 (5); e21355
  • Published Online: September 5, 2014
  • Article Type: Research Article
  • Received: June 19, 2014
  • Revised: July 6, 2014
  • Accepted: July 19, 2014
  • DOI: 10.5812/numonthly.21355

To Cite: Sedighi O, Makhlough A, Shokrzadeh M, Hoorshad S. Association Between Plasma Selenium and Glutathione Peroxidase Levels And Severity of Diabetic Nephropathy in Patients With Type Two Diabetes Mellitus, Nephro-Urol Mon. 2014 ; 6(5):e21355. doi: 10.5812/numonthly.21355.

Copyright © 2014, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Martin-Gallan P, Carrascosa A, Gussinye M, Dominguez C. Oxidative stress in childhood type 1 diabetes: Results from a study covering the first 20 years of evolution. Free Radic Res. 2007; 41(8): 919-28[DOI][PubMed]
  • 2. Pricci F, Leto G, Amadio L, Iacobini C, Cordone S, Catalano S, et al. Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C. Free Radical Biol Medic. 2003; 35(6): 683-94[DOI]
  • 3. Firoozrai M, Nourbakhsh M, Razzaghy-Azar M. Erythrocyte susceptibility to oxidative stress and antioxidant status in patients with type 1 diabetes. Diabetes Res Clin Pract. 2007; 77(3): 427-32[DOI][PubMed]
  • 4. Zachara BA, Gromadzinska J, Wasowicz W, Zbrog Z. Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review. Acta Biochim Pol. 2006; 53(4): 663-77[PubMed]
  • 5. Beytut E, Erisir M, Aksakal M. Effects of additional vitamin E and selenium supply on antioxidative defence mechanisms in the kidney of rats treated with high doses of glucocorticoid. Cell Biochem Funct. 2004; 22(1): 59-65[DOI][PubMed]
  • 6. Afshari AT, Shirpoor A, Farshid A, Saadatian R, Rasmi Y, Saboory E, et al. The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats. Food Chem. 2007; 101(1): 148-53[DOI]
  • 7. Kornhauser C, Garcia-Ramirez JR, Wrobel K, Perez-Luque EL, Garay-Sevilla ME, Wrobel K. Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Prim Care Diabetes. 2008; 2(2): 81-5[DOI][PubMed]
  • 8. Darmaun D, Smith SD, Sweeten S, Sager BK, Welch S, Mauras N. Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes. Diabetes. 2005; 54(1): 190-6[PubMed]
  • 9. Abdeyazdan Z, Hashemipour M, Hasanzadeh A, Pour Naghshban Z, Kabirzadeh M. Microalbuminuria in type 1 diabetes mellitus. . Shiraz E-Medic J. 2007; 8(1): 28-32
  • 10. Aslan M, Sabuncu T, Kocyigit A, Celik H, Selek S. Relationship between total oxidant status and severity of diabetic nephropathy in type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2007; 17(10): 734-40[DOI][PubMed]
  • 11. Gardiner PHE, Littlejohn D, Halls DJ, Fell GS. Direct Determination of Selenium in Human Blood Serum and Plasma by Electrothermal Atomic Absorption Spectrometry. Trace Elem Med Biol J. 1995; 9(2): 74-81[DOI]
  • 12. Hernandez-Marco R, Codoner-Franch P, Pons Morales S, Del Castillo Villaescusa C, Boix Garcia L, Valls Belles V. Oxidant/antioxidant status and hyperfiltration in young patients with type 1 diabetes mellitus. Pediatr Nephrol. 2009; 24(1): 121-7[DOI][PubMed]
  • 13. Aliciguzel Y, Ozen I, Aslan M, Karayalcin U. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. Lab Clin Med J. 2003; 142(3): 172-7[DOI]
  • 14. Beckett GJ, Arthur JR. Selenium and endocrine systems. J Endocrinol. 2005; 184(3): 455-65[DOI][PubMed]
  • 15. Ford ES, Giles WH, Mokdad AH, Ajani UA. Microalbuminuria and concentrations of antioxidants among US adults. Am J Kidney Dis. 2005; 45(2): 248-55[PubMed]
  • 16. Parham M, Amini M, Aminorroaya A, Heidarian E. Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: a double blind, randomized, placebo-controlled, cross-over trial. Rev Diabet Stud. 2008; 5(2): 102-9[DOI][PubMed]
  • 17. Farvid MS, Jalali M, Siassi F, Hosseini M. Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes. Diabetes Care. 2005; 28(10): 2458-64[PubMed]
  • 18. Kadhim HM, Ismail SH, Hussein KI, Bakir IH, Sahib AS, Khalaf BH, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res. 2006; 41(2): 189-93[DOI][PubMed]
  • 19. Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006; 20(1): 3-18[DOI][PubMed]
  • 20. Sedighi O, Zargari M, Varshi G. Effect of selenium supplementation on glutathione peroxidase enzyme activity in patients with chronic kidney disease: a randomized clinical trial. Nephrourol Mon. 2014; 6(3)[DOI][PubMed]
  • 21. Hayden MR, Chowdhury NA, Witte L, Sowers JR. Microalbuminuria and Proximal Tubule Remodeling in the Cardiometabolic Syndrome. CardioMetab Syndrome J. 2006; 1(2): 107-14[DOI]
  • 22. Murtaugh MA, Jacobs DR, Jr, Yu X, Gross MD, Steffes M, Coronary Artery Risk Development in Young Adults S. Correlates of urinary albumin excretion in young adult blacks and whites: the Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol. 2003; 158(7): 676-86[PubMed]
  • 23. Valgimigli M, Merli E, Malagutti P, Soukhomovskaia O, Cicchitelli G, Macri G, et al. Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress. Arch Biochem Biophys. 2003; 420(2): 255-61[PubMed]
  • 24. Ozdemir G, Ozden M, Maral H, Kuskay S, Cetinalp P, Tarkun I. Malondialdehyde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria. Ann Clin Biochem. 2005; 42: 99-104[DOI][PubMed]
  • 25. Waggiallah H, Alzohairy M. The effect of oxidative stress on human red cells glutathione peroxidase, glutathione reductase level, and prevalence of anemia among diabetics. N Am J Med Sci. 2011; 3(7): 344-7[DOI][PubMed]
  • 26. Zachara BA, Gromadzinska J, Palus J, Zbrog Z, Swiech R, Twardowska E, et al. The effect of selenium supplementation in the prevention of DNA damage in white blood cells of hemodialyzed patients: a pilot study. Biol Trace Elem Res. 2011; 142(3): 274-83[DOI][PubMed]
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