Nephro-Urology Monthly

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Nontraditional Cardiovascular Biomarkers and Estimation of Cardiovascular Risk in Predialysis Chronic Kidney Disease Patients and Their Correlations With Carotid Intima Media Thickness

Satyanand Sathi 1 , * , Himanshu Mahapatra 1 , Sham Sunder 1 , Rajesh Jayaraman 1 , Neera Sharma 2 , Himanshu Verma 1 , Venkataramanan Krishnamoorthy 1 , Anurag Gupta 1 , Prabhu Kanchi 1 , Sunil Daksh 1 , Lalit Pursnani 1 , Faisal Shadab 3 and Manveer Singh 3
Authors Information
1 Department of Nephrology, PGIMER and Dr. Ram Manohar Lohia Hospital, Indraprastha University, New Delhi, India
2 Department of Biochemistry, PGIMER and Dr. Ram Manohar Lohia Hospital, Indraprastha University, New Delhi, India
3 Department of Radiology, PGIMER and Dr. Ram Manohar Lohia Hospital, Indraprastha University, New Delhi, India
Article information
  • Nephro-Urology Monthly: November 01, 2014, 6 (6); e22112
  • Published Online: November 11, 2014
  • Article Type: Research Article
  • Received: July 17, 2014
  • Revised: July 27, 2014
  • Accepted: August 5, 2014
  • DOI: 10.5812/numonthly.22112

To Cite: Sathi S, Mahapatra H, Sunder S, Jayaraman R, Sharma N, et al. Nontraditional Cardiovascular Biomarkers and Estimation of Cardiovascular Risk in Predialysis Chronic Kidney Disease Patients and Their Correlations With Carotid Intima Media Thickness, Nephro-Urol Mon. 2014 ; 6(6):e22112. doi: 10.5812/numonthly.22112.

Copyright © 2014, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Foley RN, Parfrey PS, Harnett JD, Kent GM, Martin CJ, Murray DC, et al. Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int. 1995; 47(1): 186-92[PubMed]
  • 2. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003; 108(17): 2154-69[DOI][PubMed]
  • 3. Roberts MA, Hare DL, Ratnaike S, Ierino FL. Cardiovascular biomarkers in CKD: pathophysiology and implications for clinical management of cardiac disease. Am J Kidney Dis. 2006; 48(3): 341-60[DOI][PubMed]
  • 4. Baughman KL. B-type natriuretic peptide -- a window to the heart. N Engl J Med. 2002; 347(3): 158-9[DOI][PubMed]
  • 5. de Lemos JA, McGuire DK, Drazner MH. B-type natriuretic peptide in cardiovascular disease. Lancet. 2003; 362(9380): 316-22[DOI][PubMed]
  • 6. Wang AY, Lai KN. Use of cardiac biomarkers in end-stage renal disease. J Am Soc Nephrol. 2008; 19(9): 1643-52[DOI][PubMed]
  • 7. Bozbas H, Yildirir A, Muderrisoglu H. Cardiac enzymes, renal failure and renal transplantation. Clin Med Res. 2006; 4(1): 79-84[PubMed]
  • 8. K. Doqi Workgroup . K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis. 2005; 45(4 Suppl 3)-153[PubMed]
  • 9. Panichi V, Migliori M, De Pietro S, Taccola D, Bianchi AM, Giovannini L, et al. C-reactive protein and interleukin-6 levels are related to renal function in predialytic chronic renal failure. Nephron. 2002; 91(4): 594-600[PubMed]
  • 10. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon R3, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003; 107(3): 499-511[PubMed]
  • 11. Bakris GL. Microalbuminuria: What Is It? Why Is It Important? What Should Be Done about It? J Clin Hypertens. 2001; 3(2): 99-102[DOI]
  • 12. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003; 139(2): 137-47[PubMed]
  • 13. O'Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol. 2002; 90(10C): 18L-21L[PubMed]
  • 14. Geroulakos G, O'Gorman D, Nicolaides A, Sheridan D, Elkeles R, Shaper AG. Carotid intima-media thickness: correlation with the British Regional Heart Study risk score. J Intern Med. 1994; 235(5): 431-3[PubMed]
  • 15. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol. 1997; 146(6): 483-94[PubMed]
  • 16. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128(4): 262-9[PubMed]
  • 17. Kato A, Takita T, Maruyama Y, Kumagai H, Hishida A. Impact of carotid atherosclerosis on long-term mortality in chronic hemodialysis patients. Kidney Int. 2003; 64(4): 1472-9[DOI][PubMed]
  • 18. Benedetto FA, Mallamaci F, Tripepi G, Zoccali C. Prognostic value of ultrasonographic measurement of carotid intima media thickness in dialysis patients. J Am Soc Nephrol. 2001; 12(11): 2458-64[PubMed]
  • 19. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130(6): 461-70[PubMed]
  • 20. Modi N, Kapoor A, Kumar S, Tewari S, Garg N, Sinha N. Utility of carotid intimal medial thickness as a screening tool for evaluation of coronary artery disease in pre-transplant end stage renal disease. J Postgrad Med. 2006; 52(4): 266-70[PubMed]
  • 21. Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, et al. Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation. 1990; 82(4): 1230-42[PubMed]
  • 22. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb. 1991; 11(5): 1245-9[PubMed]
  • 23. Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002; 347(3): 161-7[DOI][PubMed]
  • 24. Weber M, Hamm C. Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart. 2006; 92(6): 843-9[DOI][PubMed]
  • 25. DeFilippi CR, Fink JC, Nass CM, Chen H, Christenson R. N-terminal pro-B-type natriuretic peptide for predicting coronary disease and left ventricular hypertrophy in asymptomatic CKD not requiring dialysis. Am J Kidney Dis. 2005; 46(1): 35-44[PubMed]
  • 26. Desai AS, Toto R, Jarolim P, Uno H, Eckardt KU, Kewalramani R, et al. Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD. Am J Kidney Dis. 2011; 58(5): 717-28[DOI][PubMed]
  • 27. Abbas NA, John RI, Webb MC, Kempson ME, Potter AN, Price CP, et al. Cardiac troponins and renal function in nondialysis patients with chronic kidney disease. Clin Chem. 2005; 51(11): 2059-66[DOI][PubMed]
  • 28. Landray MJ, Wheeler DC, Lip GY, Newman DJ, Blann AD, McGlynn FJ, et al. Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study. Am J Kidney Dis. 2004; 43(2): 244-53[PubMed]
  • 29. Caliskan Y, Ozkok A, Akagun T, Alpay N, Guz G, Polat N, et al. Cardiac biomarkers and noninvasive predictors of atherosclerosis in chronic peritoneal dialysis patients. Kidney Blood Press Res. 2012; 35(5): 340-8[DOI][PubMed]
  • 30. Menon V, Greene T, Wang X, Pereira AA, Marcovina SM, Beck GJ, et al. C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease. Kidney Int. 2005; 68(2): 766-72[DOI][PubMed]
  • 31. Szeto CC, Chow KM, Woo KS, Chook P, Ching-Ha Kwan B, Leung CB, et al. Carotid intima media thickness predicts cardiovascular diseases in Chinese predialysis patients with chronic kidney disease. J Am Soc Nephrol. 2007; 18(6): 1966-72[DOI][PubMed]
  • 32. Bakker AJ. Detection of microalbuminuria. Receiver operating characteristic curve analysis favors albumin-to-creatinine ratio over albumin concentration. Diabetes Care. 1999; 22(2): 307-13[PubMed]
  • 33. Trimarchi H, Muryan A, Dicugno M, Young P, Forrester M, Lombi F, et al. Proteinuria: an ignored marker of inflammation and cardiovascular disease in chronic hemodialysis. Int J Nephrol Renovasc Dis. 2012; 5: 1-7[DOI][PubMed]
  • 34. Ekart R, Hojs R, Hojs-Fabjan T, Balon BP. Predictive value of carotid intima media thickness in hemodialysis patients. Artif Organs. 2005; 29(8): 615-9[DOI][PubMed]
  • 35. Nishizawa Y, Shoji T, Maekawa K, Nagasue K, Okuno S, Kim M, et al. Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis. 2003; 41(3 Suppl 1)-9[DOI][PubMed]
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