Nephro-Urology Monthly

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Prevalence and Sleep Related Disorders of Restless Leg Syndrome in Hemodialysis Patients

Farzaneh Chavoshi 1 , Behzad Einollahi 2 , Khosro Sadeghniat Haghighi 1 , Maryam Saraei 1 and Neda Izadianmehr 3 , *
Authors Information
1 Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
2 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Article information
  • Nephro-Urology Monthly: March 01, 2015, 7 (2); e24611
  • Published Online: February 24, 2015
  • Article Type: Research Article
  • Received: October 15, 2014
  • Revised: November 8, 2014
  • Accepted: November 15, 2014
  • DOI: 10.5812/numonthly.24611

To Cite: Chavoshi F, Einollahi B, Sadeghniat Haghighi K, Saraei M, Izadianmehr N. Prevalence and Sleep Related Disorders of Restless Leg Syndrome in Hemodialysis Patients, Nephro-Urol Mon. 2015 ; 7(2):e24611. doi: 10.5812/numonthly.24611.

Copyright © 2015, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Kavanagh D, Siddiqui S, Geddes CC. Restless legs syndrome in patients on dialysis. Am J Kidney Dis. 2004; 43(5): 763-71[PubMed]
  • 2. Molnar MZ, Novak M, Szeifert L, Ambrus C, Keszei A, Koczy A, et al. Restless legs syndrome, insomnia, and quality of life after renal transplantation. J Psychosom Res. 2007; 63(6): 591-7[DOI][PubMed]
  • 3. Ekbom KA. Restless legs syndrome. Acta Med Scand. 1945; 158(122)
  • 4. Allen RP. Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome. Am J Med. 2007; 120(1 Suppl 1)-21[DOI][PubMed]
  • 5. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4(2): 101-19[PubMed]
  • 6. Kathy P, Mark U. ERSD patient handout,patient guide to End-Stage Renal Disease (ESRD) and RLS. NightWalkers. 2008; : 21-2
  • 7. Unruh ML, Sanders MH, Redline S, Piraino BM, Umans JG, Chami H, et al. Subjective and objective sleep quality in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the sleep heart health study. Am J Kidney Dis. 2008; 52(2): 305-13[DOI][PubMed]
  • 8. Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S, et al. Restless legs syndrome in end-stage renal disease. Sleep Med. 2004; 5(3): 309-15[DOI][PubMed]
  • 9. Einollahi B, Izadianmehr N. Restless Leg Syndrome: A Neglected Diagnosis. Nephro Urol Mon. 2014; 6(5)[DOI]
  • 10. Walters AS. Co-morbidity, morbidity and mortality in the restless legs syndrome. 2nd WASM World Congress. 2007; : 11-47
  • 11. Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003; 4(2): 121-32[PubMed]
  • 12. Johns MW. Reliability and factor analysis of the Epworth Sleepiness Scale. Sleep. 1992; 15(4): 376-81[PubMed]
  • 13. Hashmi AM, Khawaja IS, Butt Z, Umair M, Naqvi SH, Jawad Ul H. The Pittsburgh Sleep Quality Index: validation of the Urdu translation. J Coll Physicians Surg Pak. 2014; 24(2): 123-6
  • 14. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14(6): 540-5[PubMed]
  • 15. Kutner NG, Zhang R, Bliwise DL. Restless legs syndrome is underdiagnosed in the US Renal Data System. QJM. 2013; 106(5): 487[DOI][PubMed]
  • 16. Araujo SM, de Bruin VM, Nepomuceno LA, Maximo ML, Daher Ede F, Correia Ferrer DP, et al. Restless legs syndrome in end-stage renal disease: Clinical characteristics and associated comorbidities. Sleep Med. 2010; 11(8): 785-90[DOI][PubMed]
  • 17. Mucsi I, Molnar MZ, Ambrus C, Szeifert L, Kovacs AZ, Zoller R, et al. Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis. Nephrol Dial Transplant. 2005; 20(3): 571-7[DOI][PubMed]
  • 18. Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M, et al. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2006; 21(1): 184-90[DOI][PubMed]
  • 19. Bhowmik D, Bhatia M, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med. 2003; 4(2): 143-6[PubMed]
  • 20. Salman SM. Restless legs syndrome in patients on hemodialysis. Saudi J Kidney Dis Transpl. 2011; 22(2): 368-72[PubMed]
  • 21. Hui DS, Wong TY, Ko FW, Li TS, Choy DK, Wong KK, et al. Prevalence of sleep disturbances in chinese patients with end-stage renal failure on continuous ambulatory peritoneal dialysis. Am J Kidney Dis. 2000; 36(4): 783-8[DOI][PubMed]
  • 22. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004; 164(2): 196-202[DOI][PubMed]
  • 23. Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle-aged women. Hypertension. 2011; 58(5): 791-6[DOI][PubMed]
  • 24. Patrick LR. Restless legs syndrome: pathophysiology and the role of iron and folate. Altern Med Rev. 2007; 12(2): 101-12[PubMed]
  • 25. Allen R. Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med. 2004; 5(4): 385-91[DOI][PubMed]
  • 26. Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ. Profile of altered brain iron acquisition in restless legs syndrome. Brain. 2011; 134: 959-68[DOI][PubMed]
  • 27. Connor JR, Wang XS, Patton SM, Menzies SL, Troncoso JC, Earley CJ, et al. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology. 2004; 62(9): 1563-7[PubMed]
  • 28. Sloand JA, Shelly MA, Feigin A, Bernstein P, Monk RD. A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis. 2004; 43(4): 663-70[PubMed]
  • 29. Allen RP, Earley CJ. The role of iron in restless legs syndrome. Mov Disord. 2007; 22 Suppl 18-8[DOI][PubMed]
  • 30. Tan EK, Ho SC, Koh L, Pavanni R. An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation. Mov Disord. 2004; 19(11): 1365-7[DOI][PubMed]
  • 31. Tan EK, Ho SC, Eng P, Loh LM, Koh L, Lum SY, et al. Restless legs symptoms in thyroid disorders. Parkinsonism Relat Disord. 2004; 10(3): 149-51[DOI][PubMed]
  • 32. Pereira JJ, Pradella-Hallinan M, Lins Pessoa H. Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis. Clinics (Sao Paulo). 2010; 65(5): 548-54[DOI][PubMed]
  • 33. Cervenka S, Palhagen SE, Comley RA, Panagiotidis G, Cselenyi Z, Matthews JC, et al. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain. 2006; 129: 2017-28[DOI][PubMed]
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