Nephro-Urology Monthly

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The Effect of Selenium Supplementation on Acute Phase Reactants and Thyroid Function Tests in Hemodialysis Patients

Hamid Reza Omrani 1 , * , Mehrali Rahimi 2 and Kanan Nikseresht 2
Authors Information
1 Nephrology and Urology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
2 Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
Article information
  • Nephro-Urology Monthly: March 01, 2015, 7 (2); e24781
  • Published Online: March 10, 2015
  • Article Type: Research Article
  • Received: October 23, 2014
  • Revised: November 17, 2014
  • Accepted: November 29, 2014
  • DOI: 10.5812/numonthly.24781

To Cite: Omrani H R, Rahimi M, Nikseresht K. The Effect of Selenium Supplementation on Acute Phase Reactants and Thyroid Function Tests in Hemodialysis Patients, Nephro-Urol Mon. 2015 ; 7(2):e24781. doi: 10.5812/numonthly.24781.

Copyright © 2015, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis. 2000; 35(3): 469-76[PubMed]
  • 2. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int. 1999; 55(2): 648-58[DOI][PubMed]
  • 3. Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Fermo I, Foca A, et al. Inflammation is associated with carotid atherosclerosis in dialysis patients. Creed Investigators. Cardiovascular Risk Extended Evaluation in Dialysis Patients. J Hypertens. 2000; 18(9): 1207-13[PubMed]
  • 4. Chen B, Lamberts LV, Behets GJ, Zhao T, Zhou M, Liu G, et al. Selenium, lead, and cadmium levels in renal failure patients in China. Biol Trace Elem Res. 2009; 131(1): 1-12[DOI][PubMed]
  • 5. Marti del Moral L, Agil A, Navarro-Alarcon M, Lopez-Ga de la Serrana H, Palomares-Bayo M, Oliveras-Lopez MJ. Altered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk. Biol Trace Elem Res. 2011; 144(1-3): 496-503[DOI][PubMed]
  • 6. Dukkipati R, Kopple JD. Causes and prevention of protein-energy wasting in chronic kidney failure. Semin Nephrol. 2009; 29(1): 39-49[DOI][PubMed]
  • 7. Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int. 2008; 73(4): 391-8[DOI][PubMed]
  • 8. Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003; 42(5): 864-81[PubMed]
  • 9. Qureshi AR, Alvestrand A, Divino-Filho JC, Gutierrez A, Heimburger O, Lindholm B, et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol. 2002; 13 Suppl 1-36[PubMed]
  • 10. Fernandez-Reyes MJ, Alvarez-Ude F, Sanchez R, Mon C, Iglesias P, Diez JJ, et al. Inflammation and malnutrition as predictors of mortality in patients on hemodialysis. J Nephrol. 2002; 15(2): 136-43[PubMed]
  • 11. Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh MK, Ayatollahi M, Geramizadeh B, et al. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Nephrol Dial Transplant. 2013; 28(3): 716-23[DOI][PubMed]
  • 12. Fujishima Y, Ohsawa M, Itai K, Kato K, Tanno K, Turin TC, et al. Serum selenium levels are inversely associated with death risk among hemodialysis patients. Nephrol Dial Transplant. 2011; 26(10): 3331-8[DOI][PubMed]
  • 13. Russo MW, Murray SC, Wurzelmann JI, Woosley JT, Sandler RS. Plasma selenium levels and the risk of colorectal adenomas. Nutr Cancer. 1997; 28(2): 125-9[DOI][PubMed]
  • 14. Psathakis D, Wedemeyer N, Oevermann E, Krug F, Siegers CP, Bruch HP. Blood selenium and glutathione peroxidase status in patients with colorectal cancer. Dis Colon Rectum. 1998; 41(3): 328-35[PubMed]
  • 15. Drutel A, Archambeaud F, Caron P. Selenium and the thyroid gland: more good news for clinicians. Clin Endocrinol (Oxf). 2013; 78(2): 155-64[DOI][PubMed]
  • 16. Kohrle J. Thyroid hormone deiodinases--a selenoenzyme family acting as gate keepers to thyroid hormone action. Acta Med Austriaca. 1996; 23(1-2): 17-30[PubMed]
  • 17. Sarvghadi F, Khalili S, Tara A, Najafi J, Aliasgari A, Kolahi A. Thyroid Function and Volume Changes in Patients with End Stage Renal Disease, Before and After Kidney Transplantation. Int J Endocrinol Metab. 2008; 6(3): 141-8
  • 18. Lo JC, Chertow GM, Go AS, Hsu CY. Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int. 2005; 67(3): 1047-52[DOI][PubMed]
  • 19. Kassayan R, Nakhjavani M, Eghtesad M, Gouhari Hosseini L. Thyroid Function Tests in N onthyroidal Illness: Correction by Mathematical Method. Int J Endocrinol Metab. 2003; 1(1): 6-13
  • 20. Koenig JS, Fischer M, Bulant E, Tiran B, Elmadfa I, Druml W. Antioxidant status in patients on chronic hemodialysis therapy: impact of parenteral selenium supplementation. Wien Klin Wochenschr. 1997; 109(1): 13-9[PubMed]
  • 21. Ardalan MR, Tubbs RS, Shoja MM. Vitamin E and selenium co-supplementation attenuates oxidative stress in haemodialysis patients receiving intra-dialysis iron infusion. Nephrol Dial Transplant. 2007; 22(3): 973-5[DOI][PubMed]
  • 22. Sedighi O, Zargari M, Varshi G. Effect of selenium supplementation on glutathione peroxidase enzyme activity in patients with chronic kidney disease: a randomized clinical trial. Nephrourol Mon. 2014; 6(3)[DOI][PubMed]
  • 23. Makropoulos W, Heintz B, Stefanidis I. Selenium deficiency and thyroid function in acute renal failure. Ren Fail. 1997; 19(1): 129-36[PubMed]
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