Nephro-Urology Monthly

Published by: Kowsar

Hemophagocytic Syndrome, an Uncommon Complication of Microscopic Polyangitis: A Case Report From Senegal

Mouhamadou Moustapha Cisse 1 , * , Daher Abdoul Karim Omar 1 , Jean De Dieu Nzambaza 1 , Sidy Ba 1 , Awa Cheikh Ndao 2 , Abibatou Sall 3 , Cherif Mouhamed Dial 4 , Maria Faye 1 , El Hadji Fary Ka 1 , Moustapha Faye 1 , Ahmed Tall Lemrabott 1 , Abdou Niang 1 and Boucar Diouf 1
Authors Information
1 Nephrology Department, Teaching Hospital Aristide Le Dantec of Dakar, Dakar, Senegal
2 Internal Medicine Department, Teaching Hospital Aristide Le Dantec of Dakar, Dakar, Senegal
3 Hematology Department, Teaching Hospital Aristide Le Dantec of Dakar, Dakar, Senegal
4 Pathology Department, General Hospital of Grand Yoff Dakar, Dakar, Senegal
Article information
  • Nephro-Urology Monthly: November 01, 2015, 7 (6); e30284
  • Published Online: November 29, 2015
  • Article Type: Case Report
  • Received: May 26, 2015
  • Revised: August 26, 2015
  • Accepted: September 8, 2015
  • DOI: 10.5812/numonthly.30284

To Cite: Cisse M M, Abdoul Karim Omar D, Nzambaza J D D, Ba S, Ndao A C, et al. Hemophagocytic Syndrome, an Uncommon Complication of Microscopic Polyangitis: A Case Report From Senegal, Nephro-Urol Mon. 2015 ; 7(6):e30284. doi: 10.5812/numonthly.30284.

Copyright © 2015, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Larroche C. Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment. Joint Bone Spine. 2012; 79(4): 356-61[DOI][PubMed]
  • 2. Karras A, Hermine O. [Hemophagocytic syndrome]. Rev Med Interne. 2002; 23(9): 768-78[PubMed]
  • 3. Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, et al. Haemophagocytic syndrome in rheumatic patients. A systematic review. Eur Rev Med Pharmacol Sci. 2012; 16(10): 1414-24[PubMed]
  • 4. Niang A, Diallo S, Ka MM, Pouye A, Diop S, Ndongo S, et al. [Hemophagocytic syndrome complicating adult's seropositive rheumatoid arthritis]. Rev Med Interne. 2004; 25(11): 826-8[DOI][PubMed]
  • 5. Ndongo S, Pouye A, Niang A, Leye A, Mbengue M, Ka MM, et al. Syndrome d'activation macrophagique: une cause inhabituelle de fièvre aigue en milieu tropical à propos de deux observations au Sénégal. Med Afri Noire. 2007; 54(6): 317-21
  • 6. Janka GE, Lehmberg K. Hemophagocytic syndromes--an update. Blood Rev. 2014; 28(4): 135-42[DOI][PubMed]
  • 7. Michot JM, Hie M, Galicier L, Lambotte O, Michel M, Bloch-Queyrat C, et al. [Hemophagocytic lymphohistiocytosis]. Rev Med Interne. 2013; 34(2): 85-93[DOI][PubMed]
  • 8. Henter JI, Elinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society. Semin Oncol. 1991; 18(1): 29-33[PubMed]
  • 9. Imashuku S. Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment. Int J Hematol. 1997; 66(2): 135-51[PubMed]
  • 10. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007; 48(2): 124-31[DOI][PubMed]
  • 11. Fukaya S, Yasuda S, Hashimoto T, Oku K, Kataoka H, Horita T, et al. Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases. Rheumatology (Oxford). 2008; 47(11): 1686-91[DOI][PubMed]
  • 12. Kumakura S, Ishikura H, Kondo M, Murakawa Y, Kobayashi S. Hemophagocytosis associated with MPO-ANCA positive vasculitis in systemic sclerosis. Clin Exp Rheumatol. 2002; 20(3): 411-4[PubMed]
  • 13. Basnet A, Cholankeril MR. Hemophagocytic lymphohistiocytosis in a patient with Goodpasture's syndrome: a rare clinical association. Am J Case Rep. 2014; 15: 431-6[DOI][PubMed]
  • 14. Hayakawa I, Shirasaki F, Ikeda H, Oishi N, Hasegawa M, Sato S, et al. Reactive hemophagocytic syndrome in a patient with polyarteritis nodosa associated with Epstein-Barr virus reactivation. Rheumatol Int. 2006; 26(6): 573-6[PubMed]
  • 15. Cusini A, Gunthard HF, Stussi G, Schwarz U, Fehr T, Grueter E, et al. Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case. Infection. 2010; 38(5): 423-6[DOI][PubMed]
  • 16. Dhote R, Simon J, Papo T, Detournay B, Sailler L, Andre MH, et al. Reactive hemophagocytic syndrome in adult systemic disease: report of twenty-six cases and literature review. Arthritis Rheum. 2003; 49(5): 633-9[DOI][PubMed]
  • 17. Kumakura S, Ishikura H, Kondo M, Murakawa Y, Masuda J, Kobayashi S. Autoimmune-associated hemophagocytic syndrome. Mod Rheumatol. 2004; 14(3): 205-15[DOI][PubMed]
  • 18. Lambotte O, Khellaf M, Harmouche H, Bader-Meunier B, Manceron V, Goujard C, et al. Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome. Medicine (Baltimore). 2006; 85(3): 169-82[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments