Nephro-Urology Monthly

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Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats

Heihachi Migita 1 , * , Shigenori Yoshitake 1 , Yoshihiro Tange 1 , Narantsog Choijookhuu 2 and Yoshitaka Hishikawa 2
Authors Information
1 Department of Medical Engineering, Faculty of Health Sciences, Kyushu University of Health and Welfare, Yoshinomachi, Nobeoka, Japan
2 Department of Anatomy, Faculty of Medicine, Division of Histochemistry and Cell Biology, University of Miyazaki, Kyotake, Miyazaki, Japan
Article information
  • Nephro-Urology Monthly: January 01, 2016, 8 (1); e34421
  • Published Online: January 17, 2016
  • Article Type: Research Article
  • Received: November 6, 2015
  • Revised: November 24, 2015
  • Accepted: November 28, 2015
  • DOI: 10.5812/numonthly.34421

To Cite: Migita H, Yoshitake S, Tange Y, Choijookhuu N, Hishikawa Y. Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats, Nephro-Urol Mon. 2016 ; 8(1):e34421. doi: 10.5812/numonthly.34421.

Copyright © 2016, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, et al. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol. 2004; 15(8): 2115-24[DOI][PubMed]
  • 2. Daemen MA, van 't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest. 1999; 104(5): 541-9[DOI][PubMed]
  • 3. Lieberthal W, Triaca V, Koh JS, Pagano PJ, Levine JS. Role of superoxide in apoptosis induced by growth factor withdrawal. Am J Physiol. 1998; 275(5 Pt 2)-702[PubMed]
  • 4. Wen X, Murugan R, Peng Z, Kellum JA. Pathophysiology of acute kidney injury: a new perspective. Contrib Nephrol. 2010; 165: 39-45[DOI][PubMed]
  • 5. Rubinstein I, Abassi Z, Milman F, Ovcharenko E, Coleman R, Winaver J, et al. Hyperbaric oxygen treatment improves GFR in rats with ischaemia/reperfusion renal injury: a possible role for the antioxidant/oxidant balance in the ischaemic kidney. Nephrol Dial Transplant. 2009; 24(2): 428-36[DOI][PubMed]
  • 6. Tibbles PM, Edelsberg JS. Hyperbaric-oxygen therapy. N Engl J Med. 1996; 334(25): 1642-8[DOI][PubMed]
  • 7. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992; 119(3): 493-501[PubMed]
  • 8. Hishikawa Y, Tamaru N, Ejima K, Hayashi T, Koji T. Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2. Arch Histol Cytol. 2004; 67(5): 455-64[PubMed]
  • 9. Carrera Baltuylle B, Carrera Gutierrez J. [Apropos of 2 cases of giant inguinal hernia]. Rev Esp Enferm Apar Dig. 1978; 54(2): 197-202[PubMed]
  • 10. Choijookhuu N, Hino S, Oo PS, Batmunkh B, Mohmand NA, Kyaw MT, et al. Ontogenetic changes in the expression of estrogen receptor beta in mouse duodenal epithelium. Clin Res Hepatol Gastroenterol. 2015; 39(4): 499-507[DOI][PubMed]
  • 11. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathol J. 1990; 17(6): 489-503[DOI]
  • 12. Weight SC, Bell PRF, Nicholson ML. Renal ischaemia-reperfusion injury. British J Surg. 1996; 83(2): 162-70[DOI]
  • 13. Solmazgul E, Uzun G, Cermik H, Atasoyu EM, Aydinoz S, Yildiz S. Hyperbaric oxygen therapy attenuates renal ischemia/reperfusion injury in rats. Urol Int. 2007; 78(1): 82-5[DOI][PubMed]
  • 14. Ramalho RJ, de Oliveira PS, Cavaglieri RC, Silva C, Medeiros PR, Filho DM, et al. Hyperbaric oxygen therapy induces kidney protection in an ischemia/reperfusion model in rats. Transplant Proc. 2012; 44(8): 2333-6[DOI][PubMed]
  • 15. Allen J, Winterford C, Axelsen RA, Gobe GC. Effects of hypoxia on morphological and biochemical characteristics of renal epithelial cell and tubule cultures. Ren Fail. 1992; 14(4): 453-60[PubMed]
  • 16. Schumer M, Colombel MC, Sawczuk IS, Gobe G, Connor J, O'Toole KM, et al. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol. 1992; 140(4): 831-8[PubMed]
  • 17. Kantari C, Walczak H. Caspase-8 and bid: caught in the act between death receptors and mitochondria. Biochim Biophys Acta. 2011; 1813(4): 558-63[DOI][PubMed]
  • 18. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993; 53(17): 3976-85[PubMed]
  • 19. Kreisberg JI, Bulger RE, Trump BF, Nagle RB. Effects of transient hypotension on the structure and function of rat kidney. Virchows Arch B Cell Pathol. 1976; 22(2): 121-33[PubMed]
  • 20. Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G. Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol. 2009; 175(3): 1010-8[DOI][PubMed]
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