Nephro-Urology Monthly

Published by: Kowsar

Burden of Hypertension and Abnormal Glomerular Permeability in Hypertensive School Children

Adebukola B Ajite 1 , Theophilus A Aladekomo 2 , Temilade Aderounmu 2 and Wasiu A Olowu 2 , *
Authors Information
1 Department of Paediatrics, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria
2 Paediatric Nephrology and Hypertension Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
Article information
  • Nephro-Urology Monthly: July 01, 2016, 8 (4); e37568
  • Published Online: May 21, 2016
  • Article Type: Research Article
  • Received: March 3, 2016
  • Revised: March 25, 2016
  • Accepted: March 30, 2016
  • DOI: 10.5812/numonthly.37568

To Cite: Ajite A B, Aladekomo T A, Aderounmu T, Olowu W A. Burden of Hypertension and Abnormal Glomerular Permeability in Hypertensive School Children, Nephro-Urol Mon. 2016 ; 8(4):e37568. doi: 10.5812/numonthly.37568.

Copyright © 2016, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Adegoke SA, Elusiyan JBE, Olowu WA, Adeodu OO. Relationship between body mass index and blood pressure among Nigerian children aged 6-18 years. Niger Endocrine Pract. 2009; 3: 35-43
  • 2. McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ. Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr. 2007; 150(6): 640-4[DOI][PubMed]
  • 3. Hansen ML, Gunn PW, Kaelber DC. Underdiagnosis of hypertension in children and adolescents. JAMA. 2007; 298(8): 874-9[DOI][PubMed]
  • 4. Okoh BA, Alikor EA, Akani N. Prevalence of hypertension in primary school-children in Port Harcourt, Nigeria. Paediatr Int Child Health. 2012; 32(4): 208-12[DOI][PubMed]
  • 5. Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, et al. Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension. 2005; 45(4): 493-8[DOI][PubMed]
  • 6. National Kidney F. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2 Suppl 1)-266[PubMed]
  • 7. National High Blood Pressure Education Program Working Group on High Blood Pressure in C. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114(2 Suppl 4th Report): 555-61[PubMed]
  • 8. Olowu WA. Renal failure in Nigerian children: factors limiting access to dialysis. Pediatr Nephrol. 2003; 18(12): 1249-54[DOI][PubMed]
  • 9. Esezobor CI, Oniyangi O, Eke F. Paediatric dialysis services in Nigeria: availability, distribution and challenges. West Afr J Med. 2012; 31(3): 181-5[PubMed]
  • 10. Balaka B, Douti K, Gnazingbe E, Bakonde B, Agbere AD, Kessie K. Etiologies et pronostic de l'insuffisance renale de l'enfant a l'hopital universitaire de Lome. J Rech Sci Univ Lome (Togo). 2012; 14: 11-8
  • 11. Aloni MN, Nsibu CN, Meeko-Mimaniye M, Ekulu PM, Bodi JM. Acute renal failure in Congolese children: a tertiary institution experience. Acta Paediatr. 2012; 101(11): 514-8[DOI][PubMed]
  • 12. Zucchelli P, Zuccala A. Primary hypertension--how does it cause renal failure? Nephrol Dial Transplant. 1994; 9(3): 223-5[PubMed]
  • 13. Ofstad J, Horvei G, Kvam FI, Morkrid L, Sekse I, Svarstad E, et al. Glomerular hemodynamics in progressive renal disease. Kidney Int Suppl. 1992; 36-14[PubMed]
  • 14. Lurbe E, Alvarez V, Redon J. Predictors of progression in hypertensive renal disease in children. J Clin Hypertens (Greenwich). 2004; 6(4): 186-91[PubMed]
  • 15. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000; 320(7244): 1240-3[PubMed]
  • 16. Lahti-Koski M, Gill T. Obesity in childhood and adolescence. Pediatr Adolesc Med. 2004; 9: 8-10
  • 17. Chiolero A, Cachat F, Burnier M, Paccaud F, Bovet P. Prevalence of hypertension in school children based on repeated measurements and association with overweight. J Hypertens. 2007; 25(11): 2209-17[DOI][PubMed]
  • 18. Ejike CE, Ugwu C. Hyperbolic Relationship between blood pressure and body mass index in a Nigerian Adolescent Population. Webmed Cent Hypertens. 2010; 1
  • 19. Rosner B, Prineas R, Daniels SR, Loggie J. Blood pressure differences between blacks and whites in relation to body size among US children and adolescents. Am J Epidemiol. 2000; 151(10): 1007-19[PubMed]
  • 20. Sorof JM, Urbina EM, Cunningham RJ, Hogg RJ, Moxey-Mims M, Eissa MA, et al. Screening for eligibility in the study of antihypertensive medication in children: experience from the Ziac Pediatric Hypertension Study. Am J Hypertens. 2001; 14(8 Pt 1): 783-7[PubMed]
  • 21. Malcolm DD, Burns TL, Mahoney LT, Lauer RM. Factors affecting left ventricular mass in childhood: the Muscatine Study. Pediatrics. 1993; 92(5): 703-9[PubMed]
  • 22. Daniels SD, Meyer RA, Loggie JM. Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation. 1990; 82(4): 1243-8[PubMed]
  • 23. Ayoola EA. Prevalence of adolescent hypertension in Nigeria. Nig J Paediatr. 1979; 6: 18-26
  • 24. Akor F, Okolo SN, Okolo AA. Blood pressure and anthropometric measurements in healthy primary school entrants in Jos, Nigeria. SAJCH. 2010; 4(2): 42-5
  • 25. Antia-Obong OE, Antia-Obong IE. Arterial blood pressure of Nigeria urban-rural school children. Nig J Paediatr. 1991; 18: 3-11
  • 26. Asani MO, Bode-Thomas F. Blood pressure pattern and its correlates among primary school children in Jos, Nigeria. Highland Med Res J. 2006; 3(2): 51-61
  • 27. Curran JS, Barness LA. Obesity Nelson Textbook of Pediatrics. 2000; : 172-6
  • 28. Gutin B, Basch C, Shea S, Contento I, DeLozier M, Rips J, et al. Blood pressure, fitness, and fatness in 5- and 6-year-old children. JAMA. 1990; 264(9): 1123-7[PubMed]
  • 29. Sorof J, Daniels S. Obesity hypertension in children: a problem of epidemic proportions. Hypertension. 2002; 40(4): 441-7[PubMed]
  • 30. Awazu M. Epidemiology of Hypertension Pediatric Nephrology. 2009; : 1459-84
  • 31. Palatini P, Mormino P, Dorigatti F, Santonastaso M, Mos L, De Toni R, et al. Glomerular hyperfiltration predicts the development of microalbuminuria in stage 1 hypertension: the HARVEST. Kidney Int. 2006; 70(3): 578-84[DOI][PubMed]
  • 32. Iseki K, Ikemiya Y, Iseki C, Takishita S. Proteinuria and the risk of developing end-stage renal disease. Kidney Int. 2003; 63(4): 1468-74[DOI][PubMed]
  • 33. Konta T, Hao Z, Takasaki S, Abiko H, Ishikawa M, Takahashi T, et al. Clinical utility of trace proteinuria for microalbuminuria screening in the general population. Clin Exp Nephrol. 2007; 11(1): 51-5[DOI][PubMed]
  • 34. Boulware LE, Jaar BG, Tarver-Carr ME, Brancati FL, Powe NR. Screening for proteinuria in US adults: a cost-effectiveness analysis. JAMA. 2003; 290(23): 3101-14[DOI][PubMed]
  • 35. Meyer NL, Mercer BM, Friedman SA, Sibai BM. Urinary dipstick protein: a poor predictor of absent or severe proteinuria. Am J Obstet Gynecol. 1994; 170(1 Pt 1): 137-41[PubMed]
  • 36. Soonthornpun S, Thammakumpee N, Thamprasit A, Rattarasarn C, Leelawattana R, Setasuban W. The utility of conventional dipsticks for urinary protein for screening of microalbuminuria in diabetic patients. J Med Assoc Thai. 2000; 83(7): 797-803[PubMed]
  • 37. Sam R, Shaykh MS, Pegoraro AA, Khalili V, Hristea I, Singh AK, et al. The significance of trace proteinuria. Am J Nephrol. 2003; 23(6): 438-41[PubMed]
  • 38. Zeller A, Sigle JP, Battegay E, Martina B. Value of a standard urinary dipstick test for detecting microalbuminuria in patients with newly diagnosed hypertension. Swiss Med Wkly. 2005; 135(3-4): 57-61[PubMed]
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