Nephro-Urology Monthly

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Effect of Selenium Supplementation on Glutathione Peroxidase Enzyme Activity in Patients With Chronic Kidney Disease: A Randomized Clinical Trial

Omid Sedighi 1 , * , Mehryar Zargari 2 and Gharmohammad Varshi 3
Authors Information
1 Department of Nephrology, Faculty of Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
2 Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Department of Internal Medicine, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Nephro-Urology Monthly: May 01, 2014, 6 (3); e17945
  • Published Online: May 4, 2014
  • Article Type: Research Article
  • Received: February 1, 2014
  • Revised: February 11, 2014
  • Accepted: February 23, 2014
  • DOI: 10.5812/numonthly.17945

To Cite: Sedighi O, Zargari M, Varshi G. Effect of Selenium Supplementation on Glutathione Peroxidase Enzyme Activity in Patients With Chronic Kidney Disease: A Randomized Clinical Trial, Nephro-Urol Mon. 2014 ; 6(3):e17945. doi: 10.5812/numonthly.17945.

Copyright © 2014, Nephrology and Urology Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Kazi TG, Jalbani N, Kazi N, Jamali MK, Arain MB, Afridi HI, et al. Evaluation of toxic metals in blood and urine samples of chronic renal failure patients, before and after dialysis. Ren Fail. 2008; 30(7): 737-45[DOI][PubMed]
  • 2. Gonzalez Rico M, Puchades MJ, Garcia Ramon R, Saez G, Tormos MC, Miguel A. [Effect of oxidative stress in patients with chronic renal failure]. Nefrologia. 2006; 26(2): 218-25[PubMed]
  • 3. Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr. 2003; 133 Suppl 3: 933S-40S[PubMed]
  • 4. Rucker D, Thadhani R, Tonelli M. Trace element status in hemodialysis patients. Semin Dial. 2010; 23(4): 389-95[DOI][PubMed]
  • 5. Taccone-Gallucci M, Noce A, Bertucci P, Fabbri C, Manca-di-Villahermosa S, Della-Rovere FR, et al. Chronic treatment with statins increases the availability of selenium in the antioxidant defence systems of hemodialysis patients. J Trace Elem Med Biol. 2010; 24(1): 27-30[DOI][PubMed]
  • 6. Zachara BA, Gromadzinska J, Wasowicz W, Zbrog Z. Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review. Acta Biochim Pol. 2006; 53(4): 663-77[PubMed]
  • 7. Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007; 9(7): 775-806[DOI][PubMed]
  • 8. Behne D, Kyriakopoulos A. Mammalian selenium-containing proteins. Annu Rev Nutr. 2001; 21: 453-73[DOI][PubMed]
  • 9. Zachara BA, Gromadzinska J, Zbrog Z, Swiech R, Wasowicz W, Twardowska E, et al. Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase. Acta Biochim Pol. 2009; 56(1): 183-7[PubMed]
  • 10. Zachara BA, Koterska D, Trafikowska A. Macro and Trace elements; 21 workshop. 2002; : 945-51
  • 11. Wilcox CS, Tisher CC. Handbook of Nephrology and Hypertension. 2009; : 23
  • 12. Rambod M, Kovesdy CP, Kalantar-Zadeh K. Malnutrition-Inflammation Score for risk stratification of patients with CKD: is it the promised gold standard? Nat Clin Pract Nephrol. 2008; 4(7): 354-5[DOI][PubMed]
  • 13. Dounousi E, Papavasiliou E, Makedou A, Ioannou K, Katopodis KP, Tselepis A, et al. Oxidative stress is progressively enhanced with advancing stages of CKD. Am J Kidney Dis. 2006; 48(5): 752-60[DOI][PubMed]
  • 14. Ko WS, Guo CH, Yeh MS, Lin LY, Hsu GS, Chen PC, et al. Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C. World J Gastroenterol. 2005; 11(30): 4697-702[PubMed]
  • 15. Guo CH, Wang CL, Chen PC, Yang TC. Linkage of some trace elements, peripheral blood lymphocytes, inflammation, and oxidative stress in patients undergoing either hemodialysis or peritoneal dialysis. Perit Dial Int. 2011; 31(5): 583-91[DOI][PubMed]
  • 16. Zachara BA, Koterska D, Manitius J, Sadowski L, Dziedziczko A, Salak A, et al. Selenium supplementation on plasma glutathione peroxidase activity in patients with end-stage chronic renal failure. Biol Trace Elem Res. 2004; 97(1): 15-30[DOI][PubMed]
  • 17. Nishioka H, Kanauchi M, Dohi K. The role of extracellular glutathione peroxidase in diabetic nephropathy. Nephron. 2001; 87(2): 196-7[PubMed]
  • 18. Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh MK, Ayatollahi M, Geramizadeh B, et al. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Nephrol Dial Transplant. 2013; 28(3): 716-23[DOI][PubMed]
  • 19. Stanczyk M, Gromadzinska J, Wasowicz W. Roles of reactive oxygen species and selected antioxidants in regulation of cellular metabolism. Int J Occup Med Environ Health. 2005; 18(1): 15-26[PubMed]
  • 20. Zwolinska D, Grzeszczak W, Kilis-Pstrusinska K, Szprynger K, Szczepanska M. Lipid peroxidation and antioxidant enzymes in children with chronic renal failure. Pediatr Nephrol. 2004; 19(8): 888-92[DOI][PubMed]
  • 21. Zachara BA, Gromadzinska J, Palus J, Zbrog Z, Swiech R, Twardowska E, et al. The effect of selenium supplementation in the prevention of DNA damage in white blood cells of hemodialyzed patients: a pilot study. Biol Trace Elem Res. 2011; 142(3): 274-83[DOI][PubMed]
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