Nephro-Urology Monthly

Published by: Kowsar

Sertraline Prevents Hypotension During Hemodialysis: A Randomized Clinical Trial

Hamid Noshad 1 , Reza Ghorbani 2 , Sepideh Herizchi 3 , Sepideh Karkon Shayan 4 , Behnaz Ghamari 5 and Farid Karkon Shayan 1 , *
Authors Information
1 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Psychiatry, Tabriz University of Medical Sciences, Tabriz, Iran
4 Students’ Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
5 Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Article information
  • Nephro-Urology Monthly: May 2018, 10 (3); e66060
  • Published Online: March 26, 2018
  • Article Type: Research Article
  • Received: January 14, 2018
  • Accepted: March 7, 2018
  • DOI: 10.5812/numonthly.66060

To Cite: Noshad H, Ghorbani R, Herizchi S, Karkon Shayan S, Ghamari B, et al. Sertraline Prevents Hypotension During Hemodialysis: A Randomized Clinical Trial, Nephro-Urol Mon. 2018 ; 10(3):e66060. doi: 10.5812/numonthly.66060.

Copyright © 2018, Nephro-Urology Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Daugirdas JT. Pathophysiology of dialysis hypotension: an update. Am J Kidney Dis. 2001;38(4 Suppl 4):S11-7. doi: 10.1053/ajkd.2001.28090. [PubMed: 11602456].
  • 2. Stefansson BV, Brunelli SM, Cabrera C, Rosenbaum D, Anum E, Ramakrishnan K, et al. Intradialytic hypotension and risk of cardiovascular disease. Clin J Am Soc Nephrol. 2014;9(12):2124-32. doi: 10.2215/CJN.02680314. [PubMed: 25376764].
  • 3. Dheenan S, Henrich WL. Preventing dialysis hypotension: a comparison of usual protective maneuvers. Kidney Int. 2001;59(3):1175-81. doi: 10.1046/j.1523-1755.2001.0590031175.x. [PubMed: 11231376].
  • 4. Davenport A, Cox C, Thuraisingham R. Achieving blood pressure targets during dialysis improves control but increases intradialytic hypotension. Kidney Int. 2008;73(6):759-64. doi: 10.1038/ [PubMed: 18160959].
  • 5. Prakash S, Garg AX, Heidenheim AP, House AA. Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. Nephrol Dial Transplant. 2004;19(10):2553-8. doi: 10.1093/ndt/gfh420. [PubMed: 15280522].
  • 6. Sulowicz W, Radziszewski A. Pathogenesis and treatment of dialysis hypotension. Kidney Int. 2006;70:36-9. doi: 10.1038/
  • 7. Locatelli F, Altieri P, Andrulli S, Bolasco P, Sau G, Pedrini LA, et al. Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD. J Am Soc Nephrol. 2010;21(10):1798-807. doi: 10.1681/ASN.2010030280. [PubMed: 20813866].
  • 8. Mizumasa T, Hirakata H, Yoshimitsu T, Hirakata E, Kubo M, Kashiwagi M, et al. Dialysis-related hypotension as a cause of progressive frontal lobe atrophy in chronic hemodialysis patients: a 3-year prospective study. Nephron Clin Pract. 2004;97(1):c23-30. doi: 10.1159/000077592. [PubMed: 15153764].
  • 9. Mancini E, Mambelli E, Irpinia M, Gabrielli D, Cascone C, Conte F, et al. Prevention of dialysis hypotension episodes using fuzzy logic control system. Nephrol Dial Transplant. 2007;22(5):1420-7. doi: 10.1093/ndt/gfl799. [PubMed: 17299006].
  • 10. Daugirdas JT, Blake PG, Ing TS. Handbook of dialysis. Lippincott Williams & Wilkins; 2007.
  • 11. Razeghi E, Dashti-Khavidaki S, Nassiri S, Abolghassemi R, Khalili H, Hashemi Nazari SS, et al. A randomized crossover clinical trial of sertraline for intradialytic hypotension. Iran J Kidney Dis. 2015;9(4):323-30. [PubMed: 26174461].
  • 12. Yalcin AU, Sahin G, Erol M, Bal C. Sertraline hydrochloride treatment for patients with hemodialysis hypotension. Blood Purif. 2002;20(2):150-3. doi: 10.1159/000047001. [PubMed: 11818677].
  • 13. Atalay H, Solak Y, Biyik M, Biyik Z, Yeksan M, Uguz F, et al. Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients. Int Urol Nephrol. 2010;42(2):527-36. doi: 10.1007/s11255-009-9686-y. [PubMed: 19953347].
  • 14. Chan KY, Li CW, Wong H, Yip T, Chan ML, Cheng HW, et al. Use of sertraline for antihistamine-refractory uremic pruritus in renal palliative care patients. J Palliat Med. 2013;16(8):966-70. doi: 10.1089/jpm.2012.0504. [PubMed: 23777329].
  • 15. Dheenan S, Venkatesan J, Grubb BP, Henrich WL. Effect of sertraline hydrochloride on dialysis hypotension. Am J Kidney Dis. 1998;31(4):624-30. doi: 10.1053/ajkd.1998.v31.pm9531178. [PubMed: 9531178].
  • 16. Baumann P. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996;31(6):444-69. doi: 10.2165/00003088-199631060-00004. [PubMed: 8968657].
  • 17. Brewster UC, Ciampi MA, Abu-Alfa AK, Perazella MA. Addition of sertraline to other therapies to reduce dialysis-associated hypotension. Nephrology (Carlton). 2003;8(6):296-301. doi: 10.1111/j.1440-1797.2003.00216.x. [PubMed: 15012700].
  • 18. General Assembly of the World Medical A. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J Am Coll Dent. 2014;81(3):14-8. [PubMed: 25951678].
  • 19. Kooman JP, Moret K, van der Sande FM, Gerlag PG, van den Wall Bake AW, Leunissen KM. Preventing dialysis hypotension: a comparison of usual protective maneuvers. Kidney Int. 2001;60(2):802-3. doi: 10.1046/j.1523-1755.2001.060002802.x. [PubMed: 11473670].
  • 20. Daugirdas JT. Dialysis hypotension: a hemodynamic analysis. Kidney Int. 1991;39(2):233-46. doi: 10.1038/ki.1991.28. [PubMed: 2002637].
  • 21. Wheeler DC. Cardiovascular disease in patients with chronic renal failure. Lancet. 1996;348(9043):1673-4. doi: 10.1016/S0140-6736(05)65816-3. [PubMed: 8973424].
  • 22. Assimon MM, Flythe JE. Intradialytic Blood Pressure Abnormalities: The Highs, The Lows and All That Lies Between. Am J Nephrol. 2015;42(5):337-50. doi: 10.1159/000441982. [PubMed: 26584275].
  • 23. Palmer BF, Henrich WL. Recent advances in the prevention and management of intradialytic hypotension. J Am Soc Nephrol. 2008;19(1):8-11. doi: 10.1681/ASN.2007091006. [PubMed: 18178796].
  • 24. Perazella MA. Pharmacologic options available to treat symptomatic intradialytic hypotension. Am J Kidney Dis. 2001;38(4 Suppl 4):S26-36. doi: 10.1053/ajkd.2001.28092. [PubMed: 11602458].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments