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Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review

AUTHORS

Adarsh Vijay1 1 , * , Arun Vijay 2 , Preethy Pankaj 3

1 Department of Surgery, Lords Hospital, Anayara, Trivandrum, drvjady01@yahoo.co.in, India

2 PGY-II, Family Medicine Residency, Howard University Hospital, USA

3 Department of Medicine, Lords Hospital, Anayara, Trivandrum, India

How to Cite: Vijay1 A, Vijay A, Pankaj P. Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review, Nephro-Urol Mon. Online ahead of Print ; 2(1):172-192.

ARTICLE INFORMATION

Nephro-Urology Monthly: 2 (1); 172-192
Article Type: Review Article
Received: July 31, 2009
Accepted: August 18, 2009

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Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of end stage renal disease and accounts for a substantial number of dialysis and transplant patients worldwide. Studies over the years have revealed precious information about the disorder's genetic profile, pathogenesis, systemic manifestations and its progression. An increased understanding of these aspects has enabled the development of clinical trials and potentially effective treatments.Relevant data on this topic was procured and synthesized with the aid of a comprehensive Medline search in addition to nephrologic and urologic literature review on ADPKD. The article provides an in-depth review into the natural history and pathogenesis of ADPKD; various clinical manifestations; progression of the disease; accuracy, reliability and need of screening and diagnostic procedures in different age groups; and novel therapeutic approaches that are being evaluated in ADPKD.

Keywords

Polycystic Kidney Autosomal Dominant

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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