Obesity as an Independent Risk Factor for the Development of Microalbuminuria

AUTHORS

Malleshappa Pavan 1 , * , Ravi Ranganath 2 , Anup P Chudhari 2 , Meenakshi Shetty 3

1 Department of Nephrology, Lilavati Hospital and Research Centre, dr_pavanm@yahoo.co.in, India

2 Department of Nephrology, Lilavati Hospital and Research Centre, India

3 Department of Medicine, Kasturba Medical College, India

How to Cite: Pavan M, Ranganath R, Chudhari A, Shetty M. Obesity as an Independent Risk Factor for the Development of Microalbuminuria, Nephro-Urol Mon. Online ahead of Print ; 3(4):276-279.

ARTICLE INFORMATION

Nephro-Urology Monthly: 3 (4); 276-279
Article Type: Research Article
Received: February 4, 2011
Accepted: April 16, 2011

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Abstract

Background: Obesity is one of the important risk factors for coronary heart disease (CHD), hypertension, diabetes and dyslipidemia. This constellation of risk factors is also associated with end-stage renal disease (ESRD), the prevalence of which has increased despite the availability of interventions to control blood sugar and blood pressure and because albuminuria appears early in the natural history of kidney disease, it’s a potential target of primary prevention
Objectives: Obesity is common in adults and likely has a causal role for Kidney disease incidence and progression. The aim of this study was to evaluate the association of obesity defined as per Asia-Pacific guidelines with microalbuminuria which is an early marker of kidney disease in adults.
Patients and Methods: Observational study based on 120 obese and 120 healthy individuals between 30-70 years of age. Urine albumin-to-creatinine ratio and body mass index (kg/m2) were measured among healthy and obese individuals at Kasturba Medical College, Mangalore, India.
Results: There was a strong association between obesity and microalbuminuria. Microalbuminuria was highly prevalent among obese subjects compared to the controls (OR = 15.33, 95% CI: 5.83 to 40.32, P < 0.001).
Conclusions: This study supports a significant association between obesity and the presence of microalbuminuria in adults. Given the increasing prevalence of obesity, this association is particularly alarming. A prospective study of the relationship between obesity and early markers of kidney damage in adults is warranted.

 


  • Implication for health policy/practice/research/medical education:
    Studies are urgently needed to determine the safe approaches for effective and sustained weight loss in order to prevent kidney damage in obese individuals.
  • Please cite this paper as:
    Pavan M, Ranganath R, Chaudhari AP, Shetty M. Obesity as an Independent Risk Factor for the Development of Microalbuminuria. Nephro-Urol Mon. 2011;3(4):276-9.
 

©2011 Kowsar M.P.Co. All rights reserved.


 

Keywords

Obesity End-stage renal disease Albuminuria Dyslipidemia

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