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Protective effect of erdosteine on cyclosporine induced chronic nephrotoxicity in rats

AUTHORS

Ebru Uz 1 , Burak Uz 1 , Arif Kaya 1 , Derya Akdeniz 2 , * , Nuket Bavbek Ruzgaresen 1 , Efkan Uz 1 , Faruk Hilmi Turgut 1 , Reyhan Bayrak 1 , Ali Akcay 1

1 Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, Fatih University, Turkey

2 Department of Internal Medicine, Faculty of Medicine, Fatih University, dr.deryaakdenizz@hotmail.com, Turkey

How to Cite: Uz E, Uz B, Kaya A, Akdeniz D, Ruzgaresen N, et al. Protective effect of erdosteine on cyclosporine induced chronic nephrotoxicity in rats, Nephro-Urol Mon. Online ahead of Print ; 3(4):280-284.

ARTICLE INFORMATION

Nephro-Urology Monthly: 3 (4); 280-284
Article Type: Research Article
Received: May 23, 2011
Accepted: June 5, 2011

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Abstract

Background: Cyclosporine (CsA) is a clinically used immunosuppressive agent; but nephrotoxicity is a serious side effect of this drug. Some antioxidants may be used to diminish oxidative stress related to cyclosporine.

Objectives: The aim of this study was to determine the protective effect of erdosteine on CsA induced chronic nephrotoxicity.

Materials and Methods: We assessed oxidative stress enzymes (SOD, CAT, GSHPx, MDA, NO and PC levels) and light microscopic changes before and after erdosteine treatment in damaged kidney. The rats were assigned randomly to one to four groups. These were: control group (n = 8), CsA group (15 mg/kg day, n = 8), erdosteine treated group (10 mg/kg day orally, n = 8) and CsA + erdosteine group (n = 8). CsA nephrotoxicity was induced by administrating oral dose of 15 mg/kg CsA daily for 21 days.

Results: We observed that the activities of glutathione peroxidase (GSHPx) were higher and MDA, NO activities were lower in CsA plus erdosteine group than in CsA group. Histological parameters significantly improved after erdosteine treatment.

Conclusions: Erdosteine does seem to have a protective effect on CsA nephrotoxicity by reducing oxidative stress.

 


Implication for health policy/practice/research/medical education:

As an exogenous antioxidant agent; erdosteine may return CsA nephrotoxicity by reducing its effect on lipid peroxidation and glomerular ROS production.


Please cite this paper as:

Uz E, Uz B, Kaya A, Akdeniz D, Ruzgaresen NB, Uz E, et al. The Protective Effect of erdosteine on Cyclosporine Induced Chronic Nephrotoxicity at Rats. Nephro-Urol Mon. 2011;3(4):x-x.


Keywords

Erdosteine Cyclosporine Oxidative stress

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