Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer
Nephro-Urology Monthly: 4 (1); 345-349
December 19, 2011
Article Type: Review Article
July 5, 2011
July 29, 2011
M . Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer,
Online ahead of Print
Bladder cancer represents a major health care burden in many societies. Currently, cystoscopy and urinary cytology are the gold standard in bladder cancer detection. To further improve detection and/or to reduce expensive and invasive cystoscopies, highly sensitive and specific urine-based tumour markers are requested. Until now, several urine-based tumour markers for the detection and surveillance of bladder cancer have been developed and are commercially available. Others are under research. This paper gives an overview of the currently commercially available urine-based tumour makers for bladder cancer. Information is based on a non-systematic PubMed literature search. All markers were at least in some studies superior to urinary cytology; however, none of them can be considered sensitive and specific enough alone to substantially reduce the necessity of cystoscopies. The recommended use of urine-based tumour markers therefore remains in adjunction to cystoscopy and for some of them in individual screening situations of patients at high risk.
Implication for health policy/practice/research/medical education: Urine-based tumour markers might become a helpful tool in early detection of bladder cancer. This review is adressed to health professionals dealing with bladder cancer patients and patients at risk.
Please cite this paper as: Horstmann M. Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer. Nephro-Urol Mon.2012;4(1): 345-9. DOI: 10.5812/kowsar.22517006.1841
Copyright © 2012, Kowsar M.P.Co. All rights reserved.
Urinary Bladder Neoplasms; Epidemiology; Tumor Markers, Biological; Diagnosis
© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.