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Hyponatremia Due to Pulmonary Tuberculosis: Review of 200 Cases


Nematollah Jonaidi Jafari 1 , Morteza Izadi 1 , Farhad Sarrafzadeh 2 , Amir Heidari 3 , Reza Ranjbar 4 , Amin Saburi 5 , *

1 Health Research Center, Baqiyatallah University of Medical Sciences, IR Iran

2 Department of Internal Medicine, Infectious Ward, Afzalipour Educational Medical Center, Kerman University of Medical Sciences, IR Iran

3 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, IR Iran

4 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, IR Iran

5 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences,, IR Iran

How to Cite: Jonaidi Jafari N, Izadi M, Sarrafzadeh F, Heidari A, Ranjbar R, et al. Hyponatremia Due to Pulmonary Tuberculosis: Review of 200 Cases, Nephro-Urol Mon. Online ahead of Print ; 5(1):687-691. doi: 10.5812/numonthly.7091.


Nephro-Urology Monthly: 5 (1); 687-691
Published Online: December 15, 2012
Article Type: Research Article
Received: July 4, 2012
Accepted: September 10, 2012




Background: Pulmonary Tuberculosis (PTB) is one of the common diseases with high prevalence of mortality and morbidity in developing countries. Various complications have been reported along with PTB. The subclinical electrolyte imbalances are customary in cases with PTB.

Objectives: The aim of this study was the evaluation of patients with PTB and hyponatremia.

Patients and Methods: We evaluated patients with diagnosis of secondary PTB who have been admitted to Baqiyatallah hospital, Tehran, Iran from 2005 till 2010. The diagnosis of PTB was based on the appearance of acid fast bacilli in sputum smears or sputum cultures, without any evidence of miliary TB. Demographic and laboratory characteristics relative to electrolytes were recorded according inclusion and exclusion criteria.

Results: The mean age was 59.22 20.57 years and 91 (45.5%) patients were male. The mean serum sodium concentration was 134.54 4.95 mmol/L and more than half of subjects (51%) have shown hyponatremia. The mean age difference between hyponatremic and eunatremic groups was statistically significant (61.95 versus 56.02 years ,respectively) (P = 0.047). No significant relationship was found between hyponatremia and gender, anti-TB medications and co-morbidity conditions.

Conclusions: In this study, an older age was suggested as an important predisposing factor for hyponatremia in patients with PTB which had been observed as less of a determinant. We recommend further evaluations for hyponatremia in patients presenting with PTB, particularly for those who are older.


Tuberculosis Hyponatremia Causality

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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