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Analgesia for Prostate biopsy: efficacy of Diclofenac patch versus Diclofenac suppository as compared to Placebo during Prostate biopsy

AUTHORS

Kishore Thekke Adiyat 1 , * , Prashanth Kanagarajah 2 , Antony PG 3 , Suresh Bhat 3

1 1West Fort Hospital Punkunnam Road Thrissur, kishoreta@yahoo.com, India

2 Madras Medical College E.V.R. Periyar Salai Chennai, India

3 West Fort Hospital Punkunnam Road Thrissur, India

How to Cite: Adiyat K, Kanagarajah P, PG A, Bhat S. Analgesia for Prostate biopsy: efficacy of Diclofenac patch versus Diclofenac suppository as compared to Placebo during Prostate biopsy, Nephro-Urol Mon. Online ahead of Print ; 2(1):239-243.

ARTICLE INFORMATION

Nephro-Urology Monthly: 2 (1); 239-243
Article Type: Research Article
Received: June 12, 2009
Accepted: July 10, 2009

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Abstract

Background and Aims: Trans-rectal ultrasound guided prostate biopsy (TRUS) remains the gold standard to diagnose patients with prostate cancer. The purpose of this study is to prospectively evaluate the efficacy of diclofenac suppository versus diclofenac patch as compared to placebo, on pain reduction during prostate biopsy.

Methods: A prospective, randomized, single-blind, placebo controlled study was performed in 73 patients requiring transrectal ultrasound guided prostate biopsy (TRUS). Patients were randomly allocated to receive 100 mg diclofenac suppository or 100 mg diclofenac patch or matching placebo 1 hour prior to the procedure. They were asked to indicate on a 10 cm visual analogue scale the degree of discomfort during probe insertion, needle penetration and four hours post biopsy. Statistical analysis was done using one way ANOVA. The data was analyzed using SPSS version 10.0.

Results: Patients given diclofenac suppository and diclofenac patch had statistically significant lower four hour pain scores than those who were given placebo. There was no statistically significant difference in the pain scores between the three groups during probe insertion and needle penetration. The three groups were similar in regards to age, prostate volume, biopsy number, prostate specific antigen levels, histological diagnosis and complication rate.

Conclusions: Diclofenac in the form of a patch or suppository does not confer a superior intraprocedural analgesic effect compared to placebo, but it reduces post procedural pain to a significant extent. We do not recommend its use as a single agent analgesic for prostate biopsy but it should be used as an adjunctive analgesic for reducing post procedural pain.

Keywords

Prostate Biopsy Prostate Cancer Trans-Rectal Ultrasound Guided Biopsy Local Analgesia Local Anesthesia

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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