Favorable renal allograft and patient outcome after transplantation in patients with diabetes mellitus: a five-year single center experience

AUTHORS

Behzad Einollahi 1 , Fatemeh Heidary 1 , Hoda Einollahi 1 , Zohreh Rostami 2 , *

1 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, IR Iran

2 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, einollahi2008@gmail.com, IR Iran

How to Cite: Einollahi B, Heidary F, Einollahi H, Rostami Z. Favorable renal allograft and patient outcome after transplantation in patients with diabetes mellitus: a five-year single center experience, Nephro-Urol Mon. Online ahead of Print ; 3(4):291-295.

ARTICLE INFORMATION

Nephro-Urology Monthly: 3 (4); 291-295
Article Type: Research Article
Received: July 10, 2011
Accepted: August 17, 2011

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Abstract

Background: Diabetic patients are increasing rapidly worldwide and kidney transplantation is generally accepted as a treatment of choice in these patients with end stage kidney disease.

Objectives: We made a plan to evaluate the 5-year outcome of kidney transplantation in patients with and without DM.

Patients and Methods: Two groups of adult kidney recipients including 117 with history of DM mellitus (DM) and 135 non- DM mellitus between March 2006 and September 2009, enrolled in this study. The clinical information was retrieved from both paper records and electronic databases and additional details were obtained from phone call.

Results: From total of 252 recipients, 182 received kidney from living donors (11% living related and 89% living unrelated) and 70 from deceased donors. Renal function was preserved among the diabetic patients as same as the non-diabetic cases (median serum creatinine 1.35 mg/ dL versus 1.30 mg/ dL, P = 0.8). Triglyceride (P = 0.000), cholesterol (P = 0.000) and uric acid levels (P = 0.004) were significantly higher in patients with DM. In addition, no significant differences were seen between two groups in terms of graft survivals at univariate and multivariate analyses. There was no significant difference in patient survival between recipients with and without DM (log-rank, P = 0.2). Multivariate analysis by Cox regression showed that age and gender of recipient, donor source and DM had no adverse effect on mid-term outcome among our patients.

Conclusions: Diabetic and non-diabetic kidney transplant recipients had similar short- and mid-term graft and patient survivals.


  • Implication for health policy/practice/research/medical education:
    This article focuses on the impact of pre-transplant diabetes mellitus on renal transplant outcomes. Surprisingly, there are no enough published papers in literature on pre-transplant diabetes; on the other hand, there are a lot of studies about the new onset diabetes mellitus.
  • Please cite this paper as:
    Einollahi B, Heidary F, Einollahi H, Rostami Z. Favorable Renal Allograft and Patient Outcome after Transplantation in Patients with Diabetes Mellitus: A Five-year Single Center Experience. Nephro-Urol Mon. 2011;3(4):291-5.

c  2011 Kowsar M.P.Co. All rights reserved.


Keywords

Kidney transplantation Diabetes mellitus Graft survival Patient survival

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