Nephro-Urology Monthly

Published by: Kowsar

Prognosis and Early Prediction of Acute Kidney Injury in Critically Ill Children

Fatih Aygun 1 , *
Author Information
1 Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
Article information
  • Nephro-Urology Monthly: November 2018, 10 (6); e83423
  • Published Online: October 3, 2018
  • Article Type: Research Article
  • Received: August 18, 2018
  • Accepted: September 6, 2018
  • DOI: 10.5812/numonthly.83423

To Cite: Aygun F. Prognosis and Early Prediction of Acute Kidney Injury in Critically Ill Children, Nephro-Urol Mon. 2018 ; 10(6):e83423. doi: 10.5812/numonthly.83423.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Bailey D, Phan V, Litalien C, Ducruet T, Merouani A, Lacroix J, et al. Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study. Pediatr Crit Care Med. 2007;8(1):29-35. doi: 10.1097/01.pcc.0000256612.40265.67. [PubMed: 17251879].
  • 2. Alves SC, Tomasi CD, Constantino L, Giombelli V, Candal R, Bristot Mde L, et al. Hypomagnesemia as a risk factor for the non-recovery of the renal function in critically ill patients with acute kidney injury. Nephrol Dial Transplant. 2013;28(4):910-6. doi: 10.1093/ndt/gfs268. [PubMed: 22764195].
  • 3. Palmieri T, Lavrentieva A, Greenhalgh D. An assessment of acute kidney injury with modified RIFLE criteria in pediatric patients with severe burns. Intensive Care Med. 2009;35(12):2125-9. doi: 10.1007/s00134-009-1638-6. [PubMed: 19756500]. [PubMed Central: PMC2779390].
  • 4. Kendirli T, Ekim M, Ozcakar ZB, Yuksel S, Acar B, Ozturk-Hiismi B, et al. Renal replacement therapies in pediatric intensive care patients: Experiences of one center in Turkey. Pediatr Int. 2007;49(3):345-8. doi: 10.1111/j.1442-200X.2007.02376.x. [PubMed: 17532833].
  • 5. Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007;71(10):1028-35. doi: 10.1038/ [PubMed: 17396113].
  • 6. Andreoli SP. Acute kidney injury in children. Pediatr Nephrol. 2009;24(2):253-63. doi: 10.1007/s00467-008-1074-9. [PubMed: 19083019]. [PubMed Central: PMC2756346].
  • 7. Mak RH. Acute kidney injury in children: The dawn of a new era. Pediatr Nephrol. 2008;23(12):2147-9. doi: 10.1007/s00467-008-1014-8. [PubMed: 18936981].
  • 8. Sanchez-Pinto LN, Goldstein SL, Schneider JB, Khemani RG. Association between progression and improvement of acute kidney injury and mortality in critically ill children. Pediatr Crit Care Med. 2015;16(8):703-10. doi: 10.1097/PCC.0000000000000461. [PubMed: 26132741].
  • 9. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative Workgroup. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: The second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care. 2004;8(4):R204-12. doi: 10.1186/cc2872. [PubMed: 15312219]. [PubMed Central: PMC522841].
  • 10. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. doi: 10.1186/cc5713. [PubMed: 17331245]. [PubMed Central: PMC2206446].
  • 11. Siew ED, Davenport A. The growth of acute kidney injury: A rising tide or just closer attention to detail? Kidney Int. 2015;87(1):46-61. doi: 10.1038/ki.2014.293. [PubMed: 25229340]. [PubMed Central: PMC4281297].
  • 12. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: A cohort analysis. Crit Care. 2006;10(3):R73. doi: 10.1186/cc4915. [PubMed: 16696865]. [PubMed Central: PMC1550961].
  • 13. Ozcakar ZB, Yalcinkaya F, Altas B, Ergun H, Kendirli T, Ates C, et al. Application of the new classification criteria of the acute kidney injury network: A pilot study in a pediatric population. Pediatr Nephrol. 2009;24(7):1379-84. doi: 10.1007/s00467-009-1158-1. [PubMed: 19308461].
  • 14. Sutherland SM, Byrnes JJ, Kothari M, Longhurst CA, Dutta S, Garcia P, et al. AKI in hospitalized children: Comparing the pRIFLE, AKIN, and KDIGO definitions. Clin J Am Soc Nephrol. 2015;10(4):554-61. doi: 10.2215/CJN.01900214. [PubMed: 25649155]. [PubMed Central: PMC4386245].
  • 15. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2(1):1-138. doi: 10.1038/kisup.2012.1. [PubMed Central: PMC4089619].
  • 16. Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW. Acute kidney injury after cardiac surgery according to risk/injury/failure/loss/end-stage, acute kidney injury network, and kidney disease: Improving global outcomes classifications. J Crit Care. 2013;28(4):389-96. doi: 10.1016/j.jcrc.2012.12.008. [PubMed: 23743540].
  • 17. Fujii T, Uchino S, Takinami M, Bellomo R. Validation of the kidney disease improving global outcomes criteria for AKI and comparison of three criteria in hospitalized patients. Clin J Am Soc Nephrol. 2014;9(5):848-54. doi: 10.2215/CJN.09530913. [PubMed: 24578334]. [PubMed Central: PMC4011454].
  • 18. Zappitelli M, Moffett BS, Hyder A, Goldstein SL. Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: A retrospective cohort study. Nephrol Dial Transplant. 2011;26(1):144-50. doi: 10.1093/ndt/gfq375. [PubMed: 20591815].
  • 19. Slater MB, Gruneir A, Rochon PA, Howard AW, Koren G, Parshuram CS. Risk factors of acute kidney injury in critically ill children. Pediatr Crit Care Med. 2016;17(9):e391-8. doi: 10.1097/PCC.0000000000000859. [PubMed: 27472255].
  • 20. Soler YA, Nieves-Plaza M, Prieto M, Garcia-De Jesus R, Suarez-Rivera M. Pediatric risk, injury, failure, loss, end-stage renal disease score identifies acute kidney injury and predicts mortality in critically ill children: A prospective study. Pediatr Crit Care Med. 2013;14(4):e189-95. doi: 10.1097/PCC.0b013e3182745675. [PubMed: 23439463]. [PubMed Central: PMC4238883].
  • 21. Fortenberry JD, Paden ML, Goldstein SL. Acute kidney injury in children: An update on diagnosis and treatment. Pediatr Clin North Am. 2013;60(3):669-88. doi: 10.1016/j.pcl.2013.02.006. [PubMed: 23639662].
  • 22. Mehta P, Sinha A, Sami A, Hari P, Kalaivani M, Gulati A, et al. Incidence of acute kidney injury in hospitalized children. Indian Pediatr. 2012;49(7):537-42. doi: 10.4103/0971-4065.177731. [PubMed: 22317984].
  • 23. Williams DM, Sreedhar SS, Mickell JJ, Chan JC. Acute kidney failure: A pediatric experience over 20 years. Arch Pediatr Adolesc Med. 2002;156(9):893-900. doi: 10.1001/archpedi.156.9.893. [PubMed: 12197796].
  • 24. Gupta S, Sengar GS, Meti PK, Lahoti A, Beniwal M, Kumawat M. Acute kidney injury in pediatric intensive care unit: Incidence, risk factors, and outcome. Indian J Crit Care Med. 2016;20(9):526-9. doi: 10.4103/0972-5229.190368. [PubMed: 27688628]. [PubMed Central: PMC5027745].
  • 25. Al-Jboor W, Almardini R, Al Bderat J, Frehat M, Al Masri H, Alajloni MS. Acute kidney injury in critically ill child. Saudi J Kidney Dis Transpl. 2016;27(4):740-7. doi: 10.4103/1319-2442.185236. [PubMed: 27424691].
  • 26. Chang JW, Jeng MJ, Yang LY, Chen TJ, Chiang SC, Soong WJ, et al. The epidemiology and prognostic factors of mortality in critically ill children with acute kidney injury in Taiwan. Kidney Int. 2015;87(3):632-9. doi: 10.1038/ki.2014.299. [PubMed: 25252027].
  • 27. Volpon LC, Sugo EK, Consulin JC, Tavares TL, Aragon DC, Carlotti AP. Epidemiology and outcome of acute kidney injury according to pediatric risk, injury, failure, loss, end-stage renal disease and kidney disease: Improving Global outcomes criteria in critically ill children-A prospective study. Pediatr Crit Care Med. 2016;17(5):e229-38. doi: 10.1097/PCC.0000000000000685. [PubMed: 26890198].
  • 28. Fitzgerald JC, Basu RK, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, et al. Acute kidney injury in pediatric severe sepsis: An independent risk factor for death and new disability. Crit Care Med. 2016;44(12):2241-50. doi: 10.1097/CCM.0000000000002007. [PubMed: 27513354]. [PubMed Central: PMC5267552].
  • 29. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365-70. doi: 10.1681/ASN.2004090740. [PubMed: 16177006].

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